104632-25-9

• 常用中文名：盐酸普拉克索
• 常用英文名：Pramipexole dihydrochloride
• CAS号：104632-25-9
• 分子式：C₁₀H₁₉Cl₂N₃S
• 分子量：284.249
• 相关类别： 原料药 神经系统用药 帕金森综合症药
• 发布时间：2018-07-23 17:28:06
• 更新时间：2024-01-02 16:04:53
• Pramipexole双盐酸盐是部分和完全的D2S,D2L,D3和D4受体激动剂, Ki分别为3.9,2.2,0.5和5.1 nM。

名称

• 中文名: 盐酸普拉克索
• 英文名: pramipexole hydrochloride anhydrous
• 中文别名: S(-)-2-氨基-6-正丙氨基-4,5,6,7-四氢苯并噻唑二盐酸盐; (S)-普拉克索二盐酸化物
• 英文别名: 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride (1:2); (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine Dihydrochloride; (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride; Pramipexole hydrochloride; Pramipexole dihydrochloride; MFCD00876894; (S)-Pramipexole Dihydrochloride; (6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride; (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride; Pramipexole (dihydrochloride)

物化性质

• 沸点: 378ºC at 760 mmHg
• 熔点: 288-290ºC
• 分子式: C₁₀H₁₉Cl₂N₃S
• 分子量: 284.249
• 闪点: 182.4ºC
• 精确质量: 283.067688
• PSA: 79.18000
• LogP: 4.15830
• 外观性状: 白色结晶粉末
• 蒸汽压: 6.49E-06mmHg at 25°C
• 储存条件: Desiccate at RT

生物活性

• 描述: Pramipexole双盐酸盐是部分和完全的D2S,D2L,D3和D4受体激动剂, Ki分别为3.9,2.2,0.5和5.1 nM。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体
  信号通路 >> 神经信号通路 >> 多巴胺受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Mierau J, Schneider FJ, Ensinger HA et al. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur J Pharmacol. 1995 Jun 23;290(1):29-36.

  [2]. El-Mallakh RS, Penagaluri P, Kantamneni A et al. Long-term use of pramipexole in bipolar depression: a naturalistic retrospective chart review. Psychiatr Q. 2010 Sep;81(3):207-13.

  [3]. Perez-Lloret S, Rey MV, Ratti L, Rascol O. Pramipexole for the treatment of early Parkinson's disease. Expert Rev Neurother. 2011 Jul;11(7):925-35.

  [4]. Hametner EM, Seppi K, Poewe W. Pramipexole extended release in Parkinson's disease. Expert Rev Neurother. 2011 Sep;11(9):1229-34.

  [5]. Hametner EM, Seppi K, Poewe W. Role and clinical utility of pramipexole extended release in the treatment of early Parkinson's disease. Clin Interv Aging. 2012;7:83-8.

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

合成路线

943319-02-6 ~84% 104632-25-9

文献：INSTYTUT FARMACEUTYCZNY Patent: WO2007/75095 A1, 2007 ; Location in patent: Page/Page column 7 ;

106006-84-2 ~72% 104632-25-9

文献：Ravinder; Rajeswar Reddy; Panasa Reddy; Bandichhor, Rakeshwar Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4908 - 4913

104632-26-0 ~98% 104632-25-9

文献：Helm AG; CF Pharma Gyogyszergyarto Kft. Patent: EP1878731 A1, 2008 ; Location in patent: Page/Page column 11 ;

1001648-71-0 ~85% 104632-25-9

文献：Helm AG; CF Pharma Gyogyszergyarto Kft. Patent: EP1878731 A1, 2008 ; Location in patent: Page/Page column 11 ;

106006-83-1 ~% 104632-25-9

文献：WO2011/21214 A2, ;

104617-50-7 ~% 104632-25-9

文献：WO2011/21214 A2, ;

27514-08-5 ~% 104632-25-9

文献：WO2011/21214 A2, ;

106092-09-5 ~% 104632-25-9

文献：WO2011/21214 A2, ;

873431-80-2 ~% 104632-25-9

文献：WO2011/21214 A2, ;

上下游产品

上游产品  8
106006-84-2 104632-26-0 1001648-71-0 106006-83-1
104617-50-7 27514-08-5 106092-09-5 873431-80-2
下游产品  1
104632-26-0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%