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MDL 11,939

MDL 11,939用途

葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。

MDL 11,939名称

[ CAS 号 ]:
107703-78-6

[ 英文名 ]:
MDL 11,939

[英文别名 ]:

laminaritriose
Glemanserin

MDL 11,939生物活性

[ 描述 ]:

葛兰素(MDL11939)是5-HT2A血清素受体的有效和选择性拮抗剂(大鼠5-HT2A、兔5-HT2A和人5-HT2A的Ki分别为2.89、0.54和2.5 nM)[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

[体内研究]

葛兰素(MDL11939)抑制吗啡诱导的雄性小鼠运动活性、行为敏化和戒断症状的增加[1]。

[参考文献]

[1]. Pehek EA, et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology. 2006;31(2):265-277.

MDL 11,939物理化学性质

[ 密度 ]:
1.084g/cm3

[ 沸点 ]:
434.2ºC at 760mmHg

[ 分子式 ]:
C₂₀H₂₅NO

[ 分子量 ]:
295.41900

[ 闪点 ]:
205.6ºC

[ 精确质量 ]:
295.19400

[ PSA ]:
23.47000

[ LogP ]:
3.61260

MDL 11,939安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H400

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

MDL 11,939文献

Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.

Psychopharmacology 172(4) , 435-42, (2004)

Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chro...

Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.

Psychopharmacology 141 , 162, (1999)

This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) ...

Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.

Psychopharmacology 201(1) , 55-66, (2008)

The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as...

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