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癸二酸二丁酯

癸二酸二丁酯用途

Dibutyl sebacate (Dibutyl decanedioate) 是一种癸二酸二丁酯,主要用作塑料生产中的增塑剂。

癸二酸二丁酯名称

[ CAS 号 ]:
109-43-3

[ 中文名 ]:
癸二酸二丁酯

[ 英文名 ]:
Dibutyl sebacate

[中文别名 ]:

[英文别名 ]:

Sebacic Acid Dibutyl Ester
MFCD00001657
dibutyl ssebacate
dibutyl p-tolylphosphonate
sebacic acid di-n-butyl ester
dibutyl decanedioate
EINECS 207-395-0
Decanedioic Acid Dibutyl Ester
Di-n-butyl-sebacate
Dibutyl sebacate

癸二酸二丁酯生物活性

[ 描述 ]:

Dibutyl sebacate (Dibutyl decanedioate) 是一种癸二酸二丁酯,主要用作塑料生产中的增塑剂。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Effect of substitution of plasticizer dibutyl phthalate with dibutyl sebacate on Eudragit® RS30D drug release rate control.

癸二酸二丁酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
351.3±10.0 °C at 760 mmHg

[ 熔点 ]:
205 °C (dec.)(lit.)

[ 分子式 ]:
C₁₈H₃₄O₄

[ 分子量 ]:
314.460

[ 闪点 ]:
157.5±17.4 °C

[ 精确质量 ]:
314.245697

[ PSA ]:
52.60000

[ LogP ]:
5.97

[ 外观性状 ]:
无色或淡黄色透明液体。

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.448

[ 储存条件 ]:
室温

[ 水溶解性 ]:
hexane, toluene, ethanol and acetone: soluble

癸二酸二丁酯MSDS

癸二酸二丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VS1150000

CHEMICAL NAME :: Sebacic acid, dibutyl ester

CAS REGISTRY NUMBER :: 109-43-3

BEILSTEIN REFERENCE NO. :: 1798308

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C18-H34-O4

MOLECULAR WEIGHT :: 314.52

WISWESSER LINE NOTATION :: 4OV8VO4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 2,22,1975

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5400 ug/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(6),86,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(6),86,1990

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5400 ug/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 55(6),86,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14700 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967- Volume(issue)/page/year: 8,11,1974 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 418 gm/kg

SEX/DURATION :: male 10 week(s) pre-mating female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 7,310,1953 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84499 No. of Facilities: 67 (estimated) No. of Industries: 4 No. of Occupations: 10 No. of Employees: 2492 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84499 No. of Facilities: 400 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 4856 (estimated) No. of Female Employees: 2157 (estimated)

癸二酸二丁酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R40:Limited evidence of a carcinogenic effect. R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S36/37-S36-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VS1150000

[ 海关编码 ]:
2917131000

癸二酸二丁酯合成路线

癸二酸二丁酯上下游产品

癸二酸二丁酯上游产品

癸二酸二丁酯下游产品

癸二酸二丁酯制备

1.由癸二酸与丁醇在硫酸催化下酯化而得。催化剂的用量为0.3%，温度为130-140℃，常压下酯化约4-6h，酯化时加入0.1-0.3%活性炭。所得粗酯经中和、脱醇、压滤即得成品。原料癸二酸由蓖麻油制得。原料消耗(kg/t)癸二酸 665丁醇 525

精制方法：减压蒸馏精制。

2.硫酸铜催化合成　在装有温度计、回流冷凝器和分水器的100mL三颈瓶中，加入一定量的癸二酸、正丁醇及少量催化剂，以苯作为带水剂，待加热溶解并搅匀后，取样测定其酸值。加热回流分水，至几乎无水分出为止，稍冷后再取样测定其酸值。反应结束后，倾出反应液，催化剂不溶于反应液而留在反应瓶可重复使用。反应液分别用水、稀Na2CO3溶液、水洗涤，再用MgSO4干燥。先常压蒸出未反应的正丁醇、苯，再减压蒸馏收集168～171℃/400Pa的馏分即为产物。以硫酸铜为酯化反应催化剂，其反应条件为：0.05mol癸二酸，催化剂用量为3.0g，醇酸物质的量比为4，反应时间3.0h，带水剂12mL，癸二酸的酯化率可达97.23%。

3.十二水合硫酸铁铵为催化剂催化合成　在装有分水器、温度计和回流冷凝器的四颈瓶中，加入一定量的癸二酸、正丁醇和十二水合硫酸铁铵，待加热溶解搅拌均匀后，取样测定其酸值。然后加热回流分水，至几乎无回流水分出为止。稍冷后取样测定其酸值。利用GB1668-81方法测定其反应前后酸值的变化，计算酯化率。反应结束后，将反应液中和至弱酸性，再分别用水、10%碳酸钠水溶液、水洗涤；蒸馏，先常压蒸出正丁醇，再减压蒸馏收集172～175℃/400Pa下的馏分即为产品。

癸二酸二丁酯海关

[ 海关编码 ]: 2917131000

[ 中文概述 ]:
2917131000 癸二酸及其盐和酯。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917131000 esters of adipic acid。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

癸二酸二丁酯文献

A novel approach for honey pollen profile assessment using an electronic tongue and chemometric tools.

Anal. Chim. Acta 900 , 36-45, (2015)

Nowadays the main honey producing countries require accurate labeling of honey before commercialization, including floral classification. Traditionally, this classification is made by melissopalynolog...

Formulation considerations in the design of topical, polymeric film-forming systems for sustained drug delivery to the skin.

Eur. J. Pharm. Biopharm. 91 , 9-15, (2015)

Polymeric film-forming systems (FFSs) are potential drug delivery systems for topical application to the skin. The FFSs form thin and transparent polymeric films in situ upon solvent evaporation. Thei...

In-line NIR monitoring of key characteristics of enteric coated pellets.

Eur. J. Pharm. Biopharm. 88(3) , 847-55, (2015)

We describe the development of an in-line monitoring approach for the fluid-bed drying and coating steps for the production of enteric coated pellets by NIR. Our results show that key pellet character...

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