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SB 205384

SB 205384用途

SB-205384 是一种 GABAA 受体调节剂。SB-205384 对 GABAA 激活电流的主要影响是去除激动剂后反应衰减半衰期延长。

SB 205384名称

[ CAS 号 ]:
160296-13-9

[ 英文名 ]:
SB 205384

SB 205384生物活性

[ 描述 ]:

SB-205384 是一种 GABAA 受体调节剂。SB-205384 对 GABAA 激活电流的主要影响是去除激动剂后反应衰减半衰期延长。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. Meadows HJ, et al. Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br J Pharmacol. 1997 Aug;121(7):1334-8.

SB 205384物理化学性质

[ 密度 ]:
1.38g/cm3

[ 沸点 ]:
565.3ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₁₈N₂O₃S

[ 分子量 ]:
330.40

[ 闪点 ]:
295.7ºC

[ 精确质量 ]:
330.10400

[ PSA ]:
113.68000

[ LogP ]:
2.79780

[ 蒸汽压 ]:
1.29E-13mmHg at 25°C

[ 折射率 ]:
1.691

SB 205384安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

SB 205384文献

Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.

Mamm. Genome 21(5-6) , 247-57, (2010)

The Tail Suspension Test (TST), which measures behavioral despair, is widely used as an animal model of human depressive disorders and antidepressant efficacy. In order to identify novel genes involve...

Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons.

J. Physiol. 522 Pt 1 , 3-17, (2000)

We examined the maturation of GABAA receptor synapses in cortical pyramidal neurons cultured from embryonic rats. The decay kinetics of GABAA receptor-mediated miniature postsynaptic currents (mPSCs) ...

SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity.

Br. J. Pharmacol. 123 , 1253-1259, (1998)

1. SB-205384, and its (+) enantiomer (+)-SB-205384 were tested for their modulatory effects on human GABA(A) receptor subunit combinations expressed in Xenopus oocytes by electrophysiological methods....

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