叔丁基对苯二酚(TBHQ)

叔丁基对苯二酚(TBHQ)用途

TBHQ是可以激活 Nrf2 的抗氧化剂。

叔丁基对苯二酚(TBHQ)作用

TBHQ化学名是特丁基对苯二酚，又名叔丁基对苯二酚、叔丁基氢醌。TBHQ为白色或微红褐色结晶粉末，有一种极淡的特殊香味，几乎不溶于水（约为百分之5），溶于乙醇、乙酸乙酯、乙醚等有机溶剂。无色晶体或白色晶体性粉末。
1、TBHQ抗氧化效果十分理想，比BHA、BHT、PG强5～7倍。适用于动植物脂肪和富脂食品，特别适用于植物油中，是色拉油、调和油、高烹油首选的抗氧化剂。
2、TBHQ能有效延缓油脂氧化，提高食品的稳定性，显著地延长油脂及富脂食品的货架期。
3、TBHQ耐高温，可用于方便面、糕点及其它油炸食品，最高承受温度可达230℃以上。
4、TBHQ一剂多能，能有效抑制细菌及霉菌生长。在添加应用范围内，能抑制几乎所有细菌和酵母菌生长，对黄曲霉等危害人体健康的霉菌有很好的抑制作用。
5、TBHQ不影响食品的色泽、风味，用于含铁的食品不着色。

叔丁基对苯二酚(TBHQ)名称

[ CAS 号 ]:
1948-33-0

[ 中文名 ]:
叔丁基氢醌

[ 英文名 ]:
tert-Butylhydroquinone

[中文别名 ]:

[英文别名 ]:

Hydroquinone,tert-butyl
1,4-Benzenediol, 2-(1,1-dimethylethyl)-
2-(1,1-dimethylethyl)benzene-1,4-diol
tert-Butylhydroquinone
TBHQ
2-tert-Butylhydroquinone
Hydroquinone, t-butyl-
2-tert-butyl-1,4-dihydroxybenzene
2-(1,1-Dimethylethyl)-1,4-benzenediol
Hydroquinone, tert-butyl-

叔丁基对苯二酚(TBHQ)生物活性

[ 描述 ]:

TBHQ是可以激活 Nrf2 的抗氧化剂。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> NF-κB信号通路 >> KEAP1-Nrf2

研究领域 >> 癌症

[参考文献]

[1]. Sukumari-Ramesh S et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury After Intracerebral Hemorrhage in Mice. J Mol Neurosci. 2016 Apr;58(4):525-31.

[2]. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes

[相关活性小分子]

ML385 | 姜黄素 | 甲基巴多索隆 | 奥马索龙 | 4-辛基衣康酸 | CDDO-Im | NK-252 | 鸦胆子苦醇 | 丹参素 | KI696 | CDDO-EA | (+)-DHMEQ | 桧木醇 | 芒果苷 | 落新妇苷

叔丁基对苯二酚(TBHQ)物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
291.4±20.0 °C at 760 mmHg

[ 熔点 ]:
127-129 °C(lit.)

[ 分子式 ]:
C₁₀H₁₄O₂

[ 分子量 ]:
166.217

[ 闪点 ]:
138.7±16.4 °C

[ 精确质量 ]:
166.099380

[ PSA ]:
40.46000

[ LogP ]:
2.33

[ 外观性状 ]:
黄褐色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.545

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong bases, strong oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；水溶解度：748 mg/l 25 °C；可溶于：醇,丙酮；不溶：苯

叔丁基对苯二酚(TBHQ)MSDS

详细MSDS(安全技术说明书)

叔丁基对苯二酚(TBHQ)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX4375000

CHEMICAL NAME :: Hydroquinone, tert-butyl-

CAS REGISTRY NUMBER :: 1948-33-0

BEILSTEIN REFERENCE NO. :: 0637923

LAST UPDATED :: 199712

DATA ITEMS CITED :: 24

MOLECULAR FORMULA :: C10-H14-O2

MOLECULAR WEIGHT :: 166.24

WISWESSER LINE NOTATION :: QR DQ BX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2900 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 144 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16250 mg/kg/13W-C

TOXIC EFFECTS :: Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10054 ng/kg/12D-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 gm/kg/13W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - other changes Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 32500 mg/kg

SEX/DURATION :: female 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 39 gm/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 39 gm/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1700 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,17,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7157 No. of Facilities: 892 (estimated) No. of Industries: 12 No. of Occupations: 21 No. of Employees: 18166 (estimated) No. of Female Employees: 3687 (estimated)

叔丁基对苯二酚(TBHQ)安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36-S28A

[ 危险品运输编码 ]:
UN3077

[ WGK德国 ]:
3

[ RTECS号 ]:
MX4375000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

[ 海关编码 ]:
29072900

叔丁基对苯二酚(TBHQ)上下游产品

叔丁基对苯二酚(TBHQ)上游产品

叔丁基对苯二酚(TBHQ)下游产品

叔丁基对苯二酚(TBHQ)制备

磷酸催化法
在甲苯、对苯二酚和60%磷酸的混合物中加入异丁烯或叔丁醇，在 105 ℃ 下反应生成TBHQ，产率为89%。
硫酸催化法
在浓硫酸或磺酸存在下，对苯二酚与叔丁醇于 90 ℃ 下反应生成41.0%(mo1)的TBHQ和5.1%(mo1)的2，5-二特丁基对苯二酚。

叔丁基对苯二酚(TBHQ)海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

叔丁基对苯二酚(TBHQ)文献

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Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance ...

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