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7-乙酰氧基-4-甲基香豆素

7-乙酰氧基-4-甲基香豆素用途

7-Acetoxy-4-methylcoumarin 是一种 GST 的抑制剂。7-Acetoxy-4-methylcoumarin 在体外抑制 AFB1-DNA 结合,抑制率为36.7%。

7-乙酰氧基-4-甲基香豆素名称

[ CAS 号 ]:
2747-05-9

[ 中文名 ]:
7-乙酰氧基-4-甲基香豆素

[ 英文名 ]:
7-Acetoxy-4-methylcoumarin

[中文别名 ]:

[英文别名 ]:

4-Methylumbeliferyl acetate
4-Methylumbelliferyl Acetate
7-Aceoxy-4-MethylcouMarin
EINECS 220-386-6
MUB ACETATE
acetic acid 4-methyl-2-oxo-2H-chromen-7-yl ester
7-Acetoxy-4-methylcoumarin
7-ACETYL-4-METHYLCOUMARIN
MUACETATE
4-METHYL-7-ACETOXYCOUMARIN

7-乙酰氧基-4-甲基香豆素生物活性

[ 描述 ]:

7-Acetoxy-4-methylcoumarin 是一种 GST 的抑制剂。7-Acetoxy-4-methylcoumarin 在体外抑制 AFB1-DNA 结合,抑制率为36.7%。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 代谢酶/蛋白酶 >> 谷胱甘肽S-转移酶

[参考文献]

[1]. Feuer, G, et al. Induction of drug-metabolizing enzymes of rat liver by derivatives of coumarin. Canadian Journal of Physiology and Pharmacology, 48(4), 232–240.

[2]. Raj HG, et al. Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom. Bioorg Med Chem. 2001 May;9(5):1085-9.

7-乙酰氧基-4-甲基香豆素物理化学性质

[ 密度 ]:
1.263g/cm3

[ 沸点 ]:
371.4ºC at 760mmHg

[ 熔点 ]:
149-150 °C(lit.)

[ 分子式 ]:
C₁₂H₁₀O₄

[ 分子量 ]:
218.20500

[ 闪点 ]:
191.5ºC

[ 精确质量 ]:
218.05800

[ PSA ]:
56.51000

[ LogP ]:
2.02670

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
8.68E-06mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
−20°C

7-乙酰氧基-4-甲基香豆素MSDS

7-乙酰氧基-4-甲基香豆素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2932209090

7-乙酰氧基-4-甲基香豆素合成路线

7-乙酰氧基-4-甲基香豆素上下游产品

7-乙酰氧基-4-甲基香豆素上游产品

7-乙酰氧基-4-甲基香豆素下游产品

7-乙酰氧基-4-甲基香豆素制备

间苯二酚经环合、乙酰化而得。在反应罐内加入乙酰乙酸乙酯和间苯二酚，搅拌升温至50℃溶解，再加入硫酸（防止冲料），加热回流1h。减压蒸干，加入乙酰乙酸乙酯，回流1h，减压蒸干。加入乙酐，回流1h。冷至80℃，缓缓加入乙醇，冷至10℃，甩滤，滤饼用乙醇洗涤至中性，干燥得7-乙酰氧基-4-甲基香豆素。熔点150-153℃（乙醇母液蒸干后可作间苯二酚投料）。

7-乙酰氧基-4-甲基香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-乙酰氧基-4-甲基香豆素文献

Automated carboxylesterase assay for the evaluation of ionic liquids' human toxicity.

J. Hazard. Mater. 244-245 , 563-9, (2013)

Aiming the prediction of ionic liquids' (ILs) human toxicity, an automated carboxylesterase activity assay was developed. The method was implemented on a sequential injection analysis (SIA) system and...

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

J. Med. Chem. 48 , 2906-15, (2005)

Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of different classes, the identification of ...

Comparison of xenobiotic metabolizing enzyme activities in ex vivo human skin and reconstructed human skin models from SkinEthic.

Arch. Toxicol. 88(9) , 1681-1694, (2014)

Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been develop...

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