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7-乙氧基-4-甲基香豆素

7-乙氧基-4-甲基香豆素用途

7-乙氧基-4-甲基香豆素是香豆素衍生物,可用作哺乳动物细胞色素P450 1A1、2B4和2B6的底物探针[1][2]。

7-乙氧基-4-甲基香豆素名称

[ CAS 号 ]:
87-05-8

[ 中文名 ]:
7-乙氧基-4-甲基香豆素

[ 英文名 ]:
Maraniol

[中文别名 ]:

[英文别名 ]:

Maraniol
7-ethoxy-4-methylchromen-2-one
2H-1-Benzopyran-2-one, 7-ethoxy-4-methyl-
7-Ethoxy-4-methyl-2H-chromen-2-one
EINECS 201-721-5
MFCD00016971

7-乙氧基-4-甲基香豆素生物活性

[ 描述 ]:

7-乙氧基-4-甲基香豆素是香豆素衍生物,可用作哺乳动物细胞色素P450 1A1、2B4和2B6的底物探针[1][2]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 其他

[ 靶点 ]

CYP1A1

CYP2B6

CYP2B4

[参考文献]

[1]. Kuhn UD, et al. Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin. Exp Toxicol Pathol. 1998 Sep;50(4-6):491-6.

[2]. Liu J, et al. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry. 2016 Apr 5;55(13):1997-2007.

7-乙氧基-4-甲基香豆素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
351.4±37.0 °C at 760 mmHg

[ 熔点 ]:
114-116 °C(lit.)

[ 分子式 ]:
C₁₂H₁₂O₃

[ 分子量 ]:
204.222

[ 闪点 ]:
146.2±21.1 °C

[ 精确质量 ]:
204.078644

[ PSA ]:
39.44000

[ LogP ]:
2.90

[ 外观性状 ]:
固体;White to Gray powder to crystal

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.548

[ 储存条件 ]:
避免光

[ 水溶解性 ]:
DMF: soluble

7-乙氧基-4-甲基香豆素MSDS

7-乙氧基-4-甲基香豆素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2932209090

7-乙氧基-4-甲基香豆素合成路线

7-乙氧基-4-甲基香豆素上下游产品

7-乙氧基-4-甲基香豆素上游产品

7-乙氧基-4-甲基香豆素下游产品

7-乙氧基-4-甲基香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-乙氧基-4-甲基香豆素文献

CYP2A6: genetics, structure, regulation, and function.

Drug Metabol. Drug Interact. 27 , 73-88, (2012)

The human CYP2A gene subfamily consists of three members, CYP2A6, CYP2A7, and CYP2A13. The CYP2A6 gene is highly polymorphic with approximately 40 annotated allelic variants. Individuals homozygous fo...

Approach to detect substrates suitable to measure the coumarin 7-hydroxylase (Cyp 2a-5)-structure-activity relationships.

Arch. Pharm. (Weinheim) 327 , 299-302, (1994)

Besides coumarin, which up to now has remained the most selective substrate for the coumarin 7-hydroxylase (Coh), 7-ethoxycoumarin, quinoline, 4-methylcoumarin, 7-ethoxy-4-methylcoumarin, 7-ethoxy-4-e...

7-Aminocoumarins are substrates of cytochrome P450-isozymes.

Arch. Pharm. (Weinheim) 331 , 143-148, (1998)

N-Alkyl-7-aminocoumarins are dealkylated by murine cytochrome P450. There are differences between the N-dealkylation of secondary and tertiary amines. 7-Ethylamino-4-methylcoumarin is deethylated by i...

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