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磷酸三氯乙酯

磷酸三氯乙酯用途

三氯磷是一种有效的口服镇静药。三氯磷在体内迅速水解为三氯乙醇(TCEOH)和磷酸单钠,有助于镇静[1]。

磷酸三氯乙酯名称

[ CAS 号 ]:
306-52-5

[ 中文名 ]:
磷酸三氯乙酯

[ 英文名 ]:
triclofos

[中文别名 ]:

三氯福司

[英文别名 ]:

Triclofosum [INN-Latin]
phosphoric acid mono-(2,2,2-trichloro-ethyl) ester
O-2,2,2-trichloroethyl monophosphate
2,2,2-trichloroethylphosphate
2,2,2-trichloroethyl dihydrogenphosphate
Trichloroethyl phosphate
Triclofos [INN:BAN]
Tricloryl
Trichlophos
Trichloryl

磷酸三氯乙酯生物活性

[ 描述 ]:

三氯磷是一种有效的口服镇静药。三氯磷在体内迅速水解为三氯乙醇(TCEOH)和磷酸单钠,有助于镇静[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

三氯磷(0.5-75µg/mL；混合血浆)快速水解为TCEOH和磷酸单钠。三氯酚、三氯乙酸(TCA)、三氯乙醇(TCEOH)和水合氯醛(CH)基质效应的平均%RSD分别为13.9%、5.6%、8.9%和14.9%[1]。

[参考文献]

[1]. Sato H, et, al. Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry. Sci Rep. 2019 Jun 26;9(1):9294.

磷酸三氯乙酯物理化学性质

[ 密度 ]:
1.891 g/cm3

[ 沸点 ]:
321.2ºC at 760 mmHg

[ 分子式 ]:
C₂H₄Cl₃O₄P

[ 分子量 ]:
229.38400

[ 闪点 ]:
148.1ºC

[ 精确质量 ]:
227.89100

[ PSA ]:
76.57000

[ LogP ]:
1.46590

[ 折射率 ]:
1.53

[ 储存条件 ]:
-20°C

磷酸三氯乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM4400000

CHEMICAL NAME :: Ethanol, 2,2,2-trichloro-, dihydrogen phosphate

CAS REGISTRY NUMBER :: 306-52-5

LAST UPDATED :: 199803

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H4-Cl3-O4-P

MOLECULAR WEIGHT :: 229.38

WISWESSER LINE NOTATION :: QPQO&O1XGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1013 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(9),77,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20230 mg/kg/17W-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2835 mg/kg/45D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(9),77,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20230 mg/kg/17W-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ug/m3/24H

SEX/DURATION :: male 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(6),20,1981

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ug/m3/24H

SEX/DURATION :: male 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(6),20,1981

磷酸三氯乙酯安全信息

[ 海关编码 ]:
2919900090

磷酸三氯乙酯合成路线

详细合成路线

磷酸三氯乙酯上下游产品

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磷酸三氯乙酯下游产品

磷酸三氯乙酯海关

[ 海关编码 ]: 2919900090

[ 中文概述 ]:
HS:2919900090 其他磷酸酯及其盐（包括乳磷酸盐）（包括它们的卤化，磺化，硝化和亚硝化衍生物）增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%