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(-)-白果内酯

(-)-白果内酯用途

Bilobalide是存在于银杏中的生物活性物,具有神经保护活性。

(-)-白果内酯名称

[ CAS 号 ]:
33570-04-6

[ 中文名 ]:
白果内酯

[ 英文名 ]:
(-)-Bilobalide

[中文别名 ]:

儿茶素

[英文别名 ]:

()-Bilobalide
BILOBALIDE
MFCD00210481
(−)-Bilobalide from Ginkgo biloba leaves
(−)-Bilobalide
(-)-Bilobalide from Ginkgo biloba leaves

(-)-白果内酯生物活性

[ 描述 ]:

Bilobalide是存在于银杏中的生物活性物,具有神经保护活性。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 萜类化合物和糖苷

研究领域 >> 神经疾病

[参考文献]

[1]. Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor. Mol Pharmacol. 2011 Jul;80(1):183-90.

[2]. Shi C, Wu F, Xu J, Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. Neurochem Int. 2011 Aug;59(1):59-64.

[3]. Goldie M, Dolan S. Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats. Behav Pharmacol. 2013 Aug;24(4):298-306.

[4]. Li WZ, Wu WY, Huang H, Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia. Mol Med Rep. 2013 Sep;8(3):935-41.

[相关活性小分子]

(-)-白果内酯物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
651.7±55.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₈O₈

[ 分子量 ]:
326.299

[ 闪点 ]:
247.5±25.0 °C

[ 精确质量 ]:
326.100159

[ PSA ]:
119.36000

[ LogP ]:
-0.45

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±4.4 mmHg at 25°C

[ 折射率 ]:
1.606

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
微溶：丙酮

(-)-白果内酯MSDS

详细MSDS(安全技术说明书)

(-)-白果内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LV1665000

(-)-白果内酯文献

Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.

Free Radic. Res. 48(10) , 1206-17, (2014)

Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance...

Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Magn. Reson. Chem. 50(8) , 569-75, (2012)

The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolid...

Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.

Toxicol. Sci. 139(2) , 338-49, (2014)

Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex m...

更多文献

(-)-白果内酯

(-)-白果内酯用途

(-)-白果内酯名称

(-)-白果内酯生物活性

(-)-白果内酯物理化学性质

(-)-白果内酯MSDS

详细MSDS(安全技术说明书)

(-)-白果内酯安全信息

(-)-白果内酯文献

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