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1,4-桉叶素

1,4-桉叶素用途

1,4-Cineole 是一种天然的广泛分布的含氧单萜烯。1,4-Cineole 存在于桉树油中,可激活人 TRPM8 和 TRPA1。

1,4-桉叶素名称

[ CAS 号 ]:
470-67-7

[ 中文名 ]:
1,4-桉叶素

[ 英文名 ]:
1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane

[中文别名 ]:

1,4-按树脑

[英文别名 ]:

1-Isopropyl-4-methyl-7-oxabicyclo[2.2.1]heptane
Isocineole
1,4-Cineole (natural)
MFCD00209502
1-isopropyl-4-methyl-7-oxa-bicyclo[2.2.1]heptane
1,4-EPOXY-P-MENTHANE
1,4-Cineol
1,4-Cineole
FEMA No. 3658
p-Menthane,1,4-epoxy

1,4-桉叶素生物活性

[ 描述 ]:

1,4-Cineole 是一种天然的广泛分布的含氧单萜烯。1,4-Cineole 存在于桉树油中,可激活人 TRPM8 和 TRPA1。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[参考文献]

[1]. Rosazza JP, et al. Microbial hydroxylation of 1,4-cineole. Appl Environ Microbiol. 1987 Oct;53(10):2482-6.

[2]. Takaishi M, et al. 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1. Mol Pain. 2012 Nov 29;8:86.

1,4-桉叶素物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
173.5±8.0 °C at 760 mmHg

[ 熔点 ]:
−46 °C(lit.)

[ 分子式 ]:
C₁₀H₁₈O

[ 分子量 ]:
154.249

[ 闪点 ]:
50.7±15.3 °C

[ 精确质量 ]:
154.135757

[ PSA ]:
9.23000

[ LogP ]:
2.58

[ 外观性状 ]:
无色非固定的液体,像樟脑的芳香

[ 蒸汽压 ]:
1.7±0.3 mmHg at 25°C

[ 折射率 ]:
1.491

[ 储存条件 ]:
-20℃

1,4-桉叶素MSDS

1,4-桉叶素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS9274000

CHEMICAL NAME :: p-Menthane, 1,4-epoxy-

CAS REGISTRY NUMBER :: 470-67-7

BEILSTEIN REFERENCE NO. :: 0104974

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,291,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2327 No. of Facilities: 2350 (estimated) No. of Industries: 29 No. of Occupations: 26 No. of Employees: 38044 (estimated) No. of Female Employees: 9165 (estimated)

1,4-桉叶素安全信息

[ 符号 ]:

GHS02

[ 信号词 ]:
Warning

[ 危害声明 ]:
H226

[ 警示性声明 ]:
P210-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 风险声明 (欧洲) ]:
R10

[ 安全声明 (欧洲) ]:
S16

[ 危险品运输编码 ]:
UN 1993 3/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
OS9274000

[ 包装等级 ]:
III

[ 危险类别 ]:
3.2

1,4-桉叶素合成路线

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1,4-桉叶素文献

Inhibition by menthol and its related chemicals of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 359-67, (2013)

Transient receptor potential (TRP) vanilloid-1 (TRPV1) and melastatin-8 (TRPM8) channels play a role in transmitting sensory information in primary-afferent neurons. TRPV1 agonists at high concentrati...

1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.

Mol. Pain 8 , 86, (2012)

Essential oils are often used in alternative medicine as analgesic and anti-inflammatory remedies. However, the specific compounds that confer the effects of essential oils and the molecular mechanism...

[Analysis of the chemical constituents of essential oil from Chimonanthus zhejiangensis by GC-MS].

Zhong Yao Cai 33(3) , 385-7, (2010)

To analyze the chemical constituents of the essential oil from Chimonanthus zhejiangensis.Steam distillation was employed to extract volatile compounds of essential oil from Chimonanthus zhejiangensis...

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