α-酮-γ-甲硫基丁酸

α-酮-γ-甲硫基丁酸用途

MTOB钠是一种有效的C末端结合蛋白(CtBP)抑制剂。MTOB钠通过抑制CtBP1和CtBP2的反式激活活性来减轻由重复性头部损伤引起的神经功能障碍和神经炎症。MTOB钠盐通过从乳腺癌细胞系中的靶启动子中逐出而拮抗CtBP1和Ct bp2的转录调节活性[1][2]。

α-酮-γ-甲硫基丁酸名称

[ CAS 号 ]:
51828-97-8

[ 中文名 ]:
4-甲硫基-2-氧丁酸钠盐

[ 英文名 ]:
MTOB

[中文别名 ]:

4-甲硫基-2-氧丁酸钠

[英文别名 ]:

KMBA
MFCD00010511
sodium 4-methylsulfanyl-2-oxo-butyrate
UNII-2EZY36W75U
Sodium 4-(methylthio)-2-oxobutanoate
sodium 4-methylthio-2-oxobutyrate
Fema No. 3881
4-Methylthio-2-oxobutanoic acid sodium salt

α-酮-γ-甲硫基丁酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[ 靶点 ]

CtBP[1]

[体外研究]

MTOB钠(10 mM)导致MCF-7中40%的CtBP靶基因(包括FGF9、CTNNB1、CEBPB等)和MBA-MD-231中46%的Ct-BP靶基因显著抑制(P<0.05)；增加前上皮E-钙粘蛋白/波形蛋白比值,同时降低前间充质CD44/CD24比值,在MCF-7中有更显著的趋势(P<0.05)[2]。

[体内研究]

MTOB钠(860 mg/kg；IP,在第一次受伤后1小时和18小时)有效抑制翻正反射持续时间的增加,并显著降低神经系统严重程度评分[1]。动物模型：C57BL/6小鼠(创伤性脑损伤)[1]剂量：860mg/kg给药：IP,在第一次损伤后1小时和18小时结果：有效抑制翻正反射持续时间的增加,并显著降低NSS评分。

[参考文献]

[1]. Li H, et al. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020 Feb 4;16(7):1107-1120.

[2]. Di LJ, et al. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun. 2013;4:1449.

α-酮-γ-甲硫基丁酸物理化学性质

[ 熔点 ]:
>300ºC(lit.)

[ 分子式 ]:
C₅H₇NaO₃S

[ 分子量 ]:
170.16200

[ 精确质量 ]:
170.00100

[ PSA ]:
82.50000

[ 外观性状 ]:
固体

[ 储存条件 ]:
2-8°C

α-酮-γ-甲硫基丁酸MSDS

详细MSDS(安全技术说明书)

α-酮-γ-甲硫基丁酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 3335

[ 海关编码 ]:
2930909090

α-酮-γ-甲硫基丁酸上下游产品

α-酮-γ-甲硫基丁酸上游产品

α-酮-γ-甲硫基丁酸下游产品

α-酮-γ-甲硫基丁酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

α-酮-γ-甲硫基丁酸文献

[Effect of substrate-dependent microbialy produced ethylene on plant growth].

Mikrobiologiia 75(2) , 277-83, (2006)

Various compounds have been identified as precursors/substrates for the synthesis of ethylene (C2H4) in soil. This study was designed to compare the efficiency of four substrates, namely L-methionine ...

Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1.

Nat. Chem. Biol. 9(4) , 244-6, (2013)

We identify an Arabidopsis pyridoxal-phosphate-dependent aminotransferase, VAS1, whose loss-of-function simultaneously increases amounts of the phytohormone auxin and the ethylene precursor 1-aminocyc...

Significant enhancement of methionol production by co-expression of the aminotransferase gene ARO8 and the decarboxylase gene ARO10 in Saccharomyces cerevisiae.

FEMS Microbiol. Lett. 362 , (2015)

Methionol is an important volatile sulfur flavor compound, which can be produced via the Ehrlich pathway in Saccharomyces cerevisiae. Aminotransferase and decarboxylase are essential enzymes catalyzin...

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