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蓖麻碱

蓖麻碱用途

蓖麻碱在CCl4诱导的肝损伤中具有肝保护作用[1]。

蓖麻碱名称

[ CAS 号 ]:
524-40-3

[ 中文名 ]:
蓖麻碱

[ 英文名 ]:
RICININE

[中文别名 ]:

蓖麻鹼

[英文别名 ]:

Recinine
4-methoxy-1-methyl-2-oxopyridine-3-carbonitrile
Ritsinin
RICININE
Ricidine
Ricinin
Recinine Ricidine Ricinin Ritsinin

蓖麻碱生物活性

[ 描述 ]:

蓖麻碱在CCl4诱导的肝损伤中具有肝保护作用[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Oriakhi K, et al. Isolation, characterization, and hepatoprotective properties of betulinic acid and ricinine from Tetracarpidium conophorum seeds (Euphorbiaceae). J Food Biochem. 2021;45(3):e13288.

蓖麻碱物理化学性质

[ 密度 ]:
1.23 g/cm3

[ 沸点 ]:
370.9ºC at 760 mmHg

[ 熔点 ]:
200-201ºC

[ 分子式 ]:
C₈H₈N₂O₂

[ 分子量 ]:
164.16

[ 闪点 ]:
178.1ºC

[ 精确质量 ]:
164.05900

[ PSA ]:
55.02000

[ LogP ]:
0.26558

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.547

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

蓖麻碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT3100000

CHEMICAL NAME :: Nicotinonitrile, 1,2-dihydro-4-methoxy-1-methyl-2-oxo-

CAS REGISTRY NUMBER :: 524-40-3

BEILSTEIN REFERENCE NO. :: 0139222

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-N2-O2

MOLECULAR WEIGHT :: 164.18

WISWESSER LINE NOTATION :: T6NVJ A1 CCN DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,23,1953

蓖麻碱安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302 + H312 + H332-H319

[ 警示性声明 ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ 危害码 (欧洲) ]:
T,Xn,F

[ 风险声明 (欧洲) ]:
25-36-20/21/22-11

[ 安全声明 (欧洲) ]:
45-36/37-16

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
QT3100000

[ 海关编码 ]:
2933399090

蓖麻碱合成路线

详细合成路线

蓖麻碱上下游产品

蓖麻碱上游产品

蓖麻碱下游产品

蓖麻碱海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

蓖麻碱文献

Screening approach by ultra-high performance liquid chromatography-tandem mass spectrometry for the blood quantification of thirty-four toxic principles of plant origin. Application to forensic toxicology.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 975 , 65-76, (2014)

Plant poisonings have left their mark on history and still cause many deaths, whether intentional or accidental. The means to show toxicological evidence of such poisonings should be implemented with ...

Neutralising antibodies against ricin toxin.

PLoS ONE 6 , e20166, (2011)

The Centers for Disease Control and Prevention have listed the potential bioweapon ricin as a Category B Agent. Ricin is a so-called A/B toxin produced by plants and is one of the deadliest molecules ...

Activity of Ricinus communis (Euphorbiaceae) and ricinine against the leaf-cutting ant Atta sexdens rubropilosa (Hymenoptera: Formicidae) and the symbiotic fungus Leucoagaricus gongylophorus.

Pest Manag. Sci. 60(9) , 933-8, (2004)

The focus of this study was the identification of compounds from plant extracts for use in crop protection. This paper reports on the toxic activity of fractions of leaf extracts of Ricinus communis L...

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蓖麻碱