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9-(Β-D -呋喃核糖)嘌呤

9-(Β-D -呋喃核糖)嘌呤用途

尼布拉里是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

9-(Β-D -呋喃核糖)嘌呤名称

[ CAS 号 ]:
550-33-4

[ 中文名 ]:
9-(Β-D -呋喃核糖)嘌呤

[ 英文名 ]:
NEBULARINE

[英文别名 ]:

PURINE RIBOSIDE
ribosyl-purin
Purinosine
Ribosyl-isopurine
NEBULARINE
6-deaMinoadenosine
9-purineribonucleoside
PURINE RIBONUCLEOSIDE
ribosylpurine

9-(Β-D -呋喃核糖)嘌呤生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

9-(Β-D -呋喃核糖)嘌呤物理化学性质

[ 密度 ]:
1.91g/cm3

[ 沸点 ]:
591.6ºC at 760mmHg

[ 熔点 ]:
181-182ºC

[ 分子式 ]:
C₁₀H₁₂N₄O₄

[ 分子量 ]:
252.23

[ 闪点 ]:
311.6ºC

[ 精确质量 ]:
252.08600

[ PSA ]:
113.52000

[ 折射率 ]:
1.837

9-(Β-D -呋喃核糖)嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO9100000

CHEMICAL NAME :: 9H-Purine, 9-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 550-33-4

BEILSTEIN REFERENCE NO. :: 0091539

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H12-N4-O4

MOLECULAR WEIGHT :: 252.26

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 14,391,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,289,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,289,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 14,391,1955

9-(Β-D -呋喃核糖)嘌呤安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ RTECS号 ]:
UO9100000

[ 海关编码 ]:
2934999090

9-(Β-D -呋喃核糖)嘌呤合成路线

详细合成路线

9-(Β-D -呋喃核糖)嘌呤上下游产品

9-(Β-D -呋喃核糖)嘌呤上游产品

9-(Β-D -呋喃核糖)嘌呤下游产品

9-(Β-D -呋喃核糖)嘌呤海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%