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[Nle11]-物质P.

[Nle11]-物质P.用途

[Nle11]-Substance P 是物质 P 类似物,避免了甲硫氨酸氧化问题。

[Nle11]-物质P.名称

[ CAS 号 ]:
57462-42-7

[ 中文名 ]:
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-NLE-NH2: RPKPQQFFGL-NLE-NH2

[ 英文名 ]:
[Nle11]-Substance P

[英文别名 ]:

substance P,NleNH2(11)
Substance P,[Nle11]
[Nle11 ]-substance P
[Nle11]-Substance P

[Nle11]-物质P.生物活性

[ 描述 ]:

[Nle11]-Substance P 是物质 P 类似物,避免了甲硫氨酸氧化问题。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经激肽受体

信号通路 >> 神经信号通路 >> 神经激肽受体

研究领域 >> 神经疾病

多肽产品

[体外研究]

物质P及其类似物[Nle11] -物质P在试验中显示出相似的效力。物质P和[Nle11] -物质P的痉挛活性以相同的效力顺序保留在受刺激的豚鼠回肠中[1]。

[参考文献]

[1]. Chipkin RE, et al. In vitro activities of some synthetic substance P analogs. Arch Int Pharmacodyn Ther. 1979 Aug;240(2):193-202.

[相关活性小分子]

[Nle11]-物质P.物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₆₄H₁₀₀N₁₈O₁₃

[ 分子量 ]:
1329.592

[ 精确质量 ]:
1328.771729

[ PSA ]:
516.63000

[ LogP ]:
-0.18

[ 折射率 ]:
1.654

[Nle11]-物质P.安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[Nle11]-物质P.合成路线

详细合成路线

[Nle11]-物质P.上下游产品

[Nle11]-物质P.上游产品

[Nle11]-物质P.下游产品

[Nle11]-物质P.文献

In vitro activities of some synthetic substance P analogs.

Arch. Int. Pharmacodyn. Ther. 240 , 193, (1979)

Substance P (SP) and several analogs and fragments have been synthesized and evaluated on non-stimulated and stimulated guinea-pig ileum. In the former test system the potency order was as follows: SP...

Synthesis and biological activities of photoaffinity labeling analogues of substance P.

J. Med. Chem. 25 , 470, (1982)

Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2, SP) is an undecapeptide with important properties as a neurotransmitter and with other functions. No specific antagonists and no long-actin...

Some observations indicating a low brain uptake of [3H]Nle11-Substance P.

Pharmazie 38(2) , 108-10, (1983)

The studies concerning the problem of whether an exogenous neuropeptide is able to enter the brain tissue were extended to the undecapeptide Substance P (SP). The amount of radioactivity 15 s after in...

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