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蓟黄素

蓟黄素用途

Cirsimaritin可以较弱的靶向结合 GABAA 受体上的苯二氮平位点,并拥有抗抑郁、抗焦虑、抗接种等活性。

蓟黄素名称

[ CAS 号 ]:
6601-62-3

[ 中文名 ]:
蓟黄素

[ 英文名 ]:
Scrophulein

[英文别名 ]:

5,4'-dihydroxy-6,7-dimethoxyflavone
Flavone, 4',5-dihydroxy-6,7-dimethoxy-
6,7-Dimethoxyscutellarein
Circimaritin
7-Methylcapillarisin
cirsimartin
Scrophulein
Skrofulein
4',5-Dihydroxy-6,7-dimethoxyflavone
cirsimaritin

蓟黄素生物活性

[ 描述 ]:

Cirsimaritin可以较弱的靶向结合 GABAA 受体上的苯二氮平位点,并拥有抗抑郁、抗焦虑、抗接种等活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

信号通路 >> 神经信号通路 >> GABA受体

研究领域 >> 神经疾病

天然产物 >> 其他

[体内研究]

Cirsimaritin显着降低小鼠的焦虑。氟马西尼(2.5 mg/kg)与salvigenin,rosmanol和cirsimaritin(10 mg/kg)联合给药可降低Cirsimaritin,表明高亲和性苯二氮卓结合位点不参与这些化合物诱导的抗焦虑活性[ 1]。

[参考文献]

[1]. Abdelhalim A, et al. Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. J Pharm Pharm Sci. 2015;18(4):448-59.

[相关活性小分子]

蓟黄素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
563.6±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₇H₁₄O₆

[ 分子量 ]:
314.289

[ 闪点 ]:
211.5±23.6 °C

[ 精确质量 ]:
314.079041

[ PSA ]:
89.13000

[ LogP ]:
1.97

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.646

[ 储存条件 ]:
?20°C

蓟黄素安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H410

[ 警示性声明 ]:
P273-P301 + P310-P501

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
25-50

[ 安全声明 (欧洲) ]:
45-61

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2914509090

蓟黄素合成路线

详细合成路线

蓟黄素上下游产品

蓟黄素上游产品

蓟黄素下游产品

蓟黄素海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

蓟黄素文献

[Studies on flavonoid constituents from herbs of Artemisia ordosica II].

Zhongguo Zhong Yao Za Zhi 31(23) , 1959-61, (2006)

To study the chemical constituents of herbs of Artemisia ordosica.The chemical constituents were isolated and repeatedly purified on silica gel column and the structures were elucidated by the NMR spe...

[Study on chemical constituents from Incarvillea arguta and their accelerating PC-12 cell differentiation].

Zhongguo Zhong Yao Za Zhi 30(17) , 1335-8, (2005)

To study chemical constituents of Incarvillea arguta and their accelerating PC-12 cell differentiation.The constituents were isolated and repeatedly purified on silica gel column chromatography, and w...

[Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].

Zhongguo Zhong Yao Za Zhi 30(8) , 591-4, (2005)

To develop a quantitative method for the determination of four flavonoids in buds of Herba Artemisiae Scopariae.The sample was extracted by ultrasonic with ethyl acetate for 30 minutes and separated o...

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蓟黄素