对羟基苯乙酮

对羟基苯乙酮用途

4-Hydroxyacetophenone (P-hydroxyacetophenone) 是蒿属植物和木香属植物中主要的保肝促胆化合物,具有抗乙型肝炎病毒作用和抗炎作用。

对羟基苯乙酮作用

馨鲜酮（对羟基苯乙酮）等同产品，具有抗氧化、抗刺激、乳液稳定和广谱防腐能力。又具有较好的水溶性，解决了很多防腐剂或防腐替代产品不易添加的弊端，并具有抗刺激、抑制炎症因子的作用，为面膜中实现防腐剂的替代成为可能，故为防腐替代产品。由于其分子中含有苯环上的羟基、酮基，因此常被作为有机合成的中间体与其他化合物反应合成许多重要物质。

对羟基苯乙酮名称

[ CAS 号 ]:
99-93-4

[ 中文名 ]:
对羟基苯乙酮

[ 英文名 ]:
4-Hydroxyacetophenone

[中文别名 ]:

[英文别名 ]:

1-(4-Hydroxyphenyl)ethan-1-one
Piceol
1-Acetyl-4-hydroxybenzene
4'-Hydroxyacetophenone
QR DV1
EINECS 202-802-8
4-Acetylphenol
4-Hydroxyacetophenone
p-Acetylphenol
Phenol, p-acetyl-

对羟基苯乙酮生物活性

[ 描述 ]:

4-Hydroxyacetophenone (P-hydroxyacetophenone) 是蒿属植物和木香属植物中主要的保肝促胆化合物,具有抗乙型肝炎病毒作用和抗炎作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Ching-Wen C, et al. p-Hydroxyacetophenone suppresses nuclear factor-κB-related inflammation in nociceptive and inflammatory animal models. J Nat Med. 2017 Apr;71(2):422-432.

对羟基苯乙酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
313.0±0.0 °C at 760 mmHg

[ 熔点 ]:
132-135 °C(lit.)

[ 分子式 ]:
C₈H₈O₂

[ 分子量 ]:
136.148

[ 闪点 ]:
121.2±12.4 °C

[ 精确质量 ]:
136.052429

[ PSA ]:
37.30000

[ LogP ]:
1.42

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
10 g/L (22 ºC)

对羟基苯乙酮MSDS

对羟基苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM8750000

CHEMICAL NAME :: Acetophenone, p-hydroxy-

CAS REGISTRY NUMBER :: 99-93-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H8-O2

MOLECULAR WEIGHT :: 136.16

WISWESSER LINE NOTATION :: QR DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 41,43,1990

对羟基苯乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S37/39-S24/25-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
PC4959775

[ 海关编码 ]:
2914509090

对羟基苯乙酮合成路线

对羟基苯乙酮上下游产品

对羟基苯乙酮上游产品

对羟基苯乙酮下游产品

对羟基苯乙酮制备

由苯酚经酰化、转位而得。将苯酚和乙酰氯混合，缓缓加热直至氯化氢停止逸出，得到粗制的乙酸苯酯。加入硝基苯中，在冷却下投入三氯化铝，加完后在室温搅拌2-3h。然后倒入冷水中，加入1：3盐酸至清亮为止。用乙醚提取，再用提取液回收乙醚，然后进行水蒸气蒸馏，硝基苯及副产物邻羟基苯乙酮随时水蒸气蒸出，对羟基苯乙酮留在残液内。用乙醚提取残液，回收乙醚后冷却结晶即得粗品，用水重结晶即为成品。上述酰化操作可用乙酐代替乙酰氯，将苯酚与乙酐加热回流3h，即生成乙酸苯酯，收率约83%。在无水三氯化铝作用下转位也可不用溶剂。另外，将对氨基苯乙酮用亚硝酸钠重氮化、水解也可制得对羟基苯乙酮。

对羟基苯乙酮海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

对羟基苯乙酮文献

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