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产品名：[Perfemiker]N-(2，6-二甲基苯基氨基甲酰甲基)亚氨基二乙酸,98%
纯度：98.0%
规格：200mg
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59160-29-1

59160-29-1结构式

常用中文名：N-(2,6-二甲基苯基氨基甲酰甲基)亚氨基二乙酸
常用英文名：Lidofenin
CAS号：59160-29-1
分子式：C₁₄H₁₈N₂O₅
分子量：294.30
相关类别：化学试剂有机试剂脂肪酸
发布时间：2019-01-12 17:26:37
更新时间：2024-01-04 15:26:04
利多卡因是一种亚氨基二乙酸(IDA)衍生物。利非宁可用于肝胆研究[1]。

中文名	N-(2,6-二甲基乙酰苯胺)亚氨基二乙酸
英文名	N-(2,6-Dimethylphenylcarbamoylmethyl)iminodiacetic Acid
中文别名	尼多非林 N-(2,6-二甲基苯基氨基甲酰甲基)亚氨基二乙酸
英文别名	2-[carboxymethyl-[2-(2,6-dimethylanilino)-2-oxoethyl]amino]acetic acid EINECS 261-636-4 MFCD00038399

描述	利多卡因是一种亚氨基二乙酸(IDA)衍生物。利非宁可用于肝胆研究[1]。
相关类别	研究领域 >> 其他信号通路 >> 其他 >> 其他
参考文献	[1]. Chiotellis E, Sawas-Dimopoulou C, Koutoulidis C, Constantinides M. 99MTc-HIDA, a gallbladder imaging agent: experimental aspects. Eur J Nucl Med. 1978;3(1):41-6

密度	1.352 g/cm3
沸点	546.3ºC at 760 mmHg
熔点	210ºC (dec.)(lit.)
分子式	C₁₄H₁₈N₂O₅
分子量	294.30
闪点	284.2ºC
精确质量	294.12200
PSA	106.94000
LogP	0.78610
外观性状	白色结晶粉末
折射率	1.5110 (estimate)
储存条件	在密封的贮藏器内，并放置阴凉，干燥的地方通风保存
稳定性	避免接触水
分子结构	1、摩尔折射率：75.55 2、摩尔体积（m³/mol）：217.5 3、等张比容（90.2K）：614.7 4、表面张力（dyne/cm）：63.6 5、极化率（10^-24cm³）：29.95
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:3 3.氢键受体数量:6 4.可旋转化学键数量:7 5.互变异构体数量:3 6.拓扑分子极性表面积107 7.重原子数量:21 8.表面电荷:0 9.复杂度:373 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：未确定 2. 密度（g/cm³25℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：210 5. 沸点（ºC ，）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率（°）：未确定 8. 闪点（℉）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性(g/L，20℃)：水：未确定

Name:	N-(2 6-Dimethylphenylcarbamoyl-Methyl)-Iminodiacetic Acid 99% Material Safety Data Sheet
Synonym:	Acetic Acid, (((2,6-Xylylcarbamoyl)methyl)imino)di-; Glycine, N-(Carboxymethyl)-N-(2-((2,6-Dimethylphenyl)amino)-2-Oxoethyl)-
CAS:	59160-29-1

Section 1 - Chemical Product MSDS Name:N-(2 6-Dimethylphenylcarbamoyl-Methyl)-Iminodiacetic Acid 99% Material Safety Data Sheet
Synonym:Acetic Acid, (((2,6-Xylylcarbamoyl)methyl)imino)di-; Glycine, N-(Carboxymethyl)-N-(2-((2,6-Dimethylphenyl)amino)-2-Oxoethyl)-

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
59160-29-1	Glycine, N-(Carboxymethyl)-N-2-(2,6-Di	99	261-636-4

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 59160-29-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 213.00 - 216.00 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: C14H18N2O5
Molecular Weight: 294.30

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 59160-29-1: AH1846000 LD50/LC50:
Not available.
Carcinogenicity:
Glycine, N-(Carboxymethyl)-N-2-(2,6-Dimethylphenyl)Amino2-Oxo - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 59160-29-1: No information available.
Canada
CAS# 59160-29-1 is listed on Canada's NDSL List.
CAS# 59160-29-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 59160-29-1 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1、急性毒性：大鼠静脉注射LD50：88mg/kg，感觉器官和特别感官（眼） -瞳孔散大（瞳孔扩张）心跳变化，抑制呼吸。小鼠静脉注射LD50：1100mg/kg。

生态学数据:

对水是稍微危害的，若无政府许可，勿将材料排入周围环境

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH1846000

CHEMICAL NAME :: Acetic acid, 2,2'-(N-(2,6-dimethylphenylcarbamoylmethyl)imino)di-

CAS REGISTRY NUMBER :: 59160-29-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H18-N2-O5

MOLECULAR WEIGHT :: 294.34

WISWESSER LINE NOTATION :: QV1N1VQ1VMR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Cardiac - change in rate Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 6,1331,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJNMD9 European Journal of Nuclear Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1976- Volume(issue)/page/year: 3,41,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 168 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JNMEAQ Journal of Nuclear Medicine. (Samuel N. Turiel & Associates, Inc., 4 30 North Michigan Avenue, Chicago, IL, DElaware 7-3511) V.1- 1960- Volume(issue)/page/year: 18,997,1977

危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	S26;S36
WGK德国	3
RTECS号	AH1846000
海关编码	2924299090

87-62-7

59160-29-1

文献：Mikiciuk-Olasik, Elzbieta; Wojewoda, Emilia; Bilichowski, Ireneusz; Witczak, Malgorzata; Karwowski, Boleslaw; Wagrowska-Danilewicz, Malgorzata; Stasikowska, Olga Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 2 p. 119 - 127

上游产品 1
87-62-7
下游产品 0

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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