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36804-95-2

36804-95-2结构式
36804-95-2结构式

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中文名 去氧哈林通碱
英文名 deoxyharringtonine
中文别名 脱氧三尖杉酯碱
英文别名 (-)-deoxyharringtonine
描述 脱氧三尖杉酯碱是从三尖杉属植物中分离出来的一种生物碱,具有显著的抗白血病活性[1]。
相关类别
体外研究 脱氧三尖杉酯碱作用于 第388页白血病细胞的 IC50型值为 7.5 ng/mL此外,其对造血细胞系如 HL-60、HL-60/RV+、JURKAT、ALL3、NCEB1、JEKO、MOLT-3等具有极强的细胞毒活性[1]。
参考文献

[1]. Joseph D Eckelbarger, et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry. 2008;14(14):4293-306.   

密度 1.3g/cm3
沸点 645.8ºC at 760mmHg
分子式 C28H37NO8
分子量 515.59500
闪点 344.4ºC
精确质量 515.25200
PSA 103.76000
LogP 3.01360
折射率 1.595

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FK0279000
CHEMICAL NAME :
Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-methylbutyl)butanedioate (ester), (3(R))-
CAS REGISTRY NUMBER :
36804-95-2
LAST UPDATED :
199209
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C28-H37-N-O8
MOLECULAR WEIGHT :
515.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988