165377-43-5

• 常用中文名：Cutamesine
• 常用英文名：SA4503
• CAS号：165377-43-5
• 分子式：C₂₃H₃₂N₂O₂
• 分子量：368.51200
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 Sigma Receptor
• 发布时间：2016-06-25 17:55:54
• 更新时间：2024-01-02 11:19:54

名称

• 中文名: Cutamesine
• 英文名: 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine
• 英文别名: Cutamesine; UNII-9J7A4144BX; SA4503

物化性质

• 分子式: C₂₃H₃₂N₂O₂
• 分子量: 368.51200
• 精确质量: 368.24600
• PSA: 24.94000
• LogP: 3.37250
• 储存条件: 2-8℃

生物活性

• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> Sigma Receptor
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Matsuno K, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9.

  [2]. Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40.

  [3]. Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8.

合成路线

55455-92-0 40173-90-8 ~86% 165377-43-5

文献：Li, Yan; Wang, Xia; Zhang, Jinming; Deuther-Conrad, Winnie; Xie, Fang; Zhang, Xiaojun; Liu, Jian; Qiao, Jinping; Cui, Mengchao; Steinbach, Joerg; Brust, Peter; Liu, Boli; Jia, Hongmei Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3478 - 3491

621-79-4 ~% 165377-43-5

文献：Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683

102-92-1 ~% 165377-43-5

文献：Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683

120-20-7 ~% 165377-43-5

文献：Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683

621-82-9 ~% 165377-43-5

文献：Fujimura, Ken-Ichi; Matsumoto, Junzo; Niwa, Masashi; Kobayashi, Tadayuki; Kawashima, Yoichi; In, Yasuko; Ishida, Toshimasa Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1675 - 1683

637-59-2 ~% 165377-43-5

文献：Li, Yan; Wang, Xia; Zhang, Jinming; Deuther-Conrad, Winnie; Xie, Fang; Zhang, Xiaojun; Liu, Jian; Qiao, Jinping; Cui, Mengchao; Steinbach, Joerg; Brust, Peter; Liu, Boli; Jia, Hongmei Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3478 - 3491

上下游产品

上游产品  7
55455-92-0 40173-90-8 621-79-4 102-92-1
120-20-7 621-82-9 637-59-2
下游产品  0