13951-70-7

• 常用中文名：16α-羟基泼尼松龙
• 常用英文名：16α-Hydroxyprednisolone
• CAS号：13951-70-7
• 分子式：C₂₁H₂₈O₆
• 分子量：376.443
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-04-12 08:00:00
• 更新时间：2024-01-02 16:10:11
• 16α-Hydroxyprednisolone 是糖皮质激素布地奈德的 22(R) epimer 构型经过 CYP3A 酶代谢生成的代谢物。

名称

• 中文名: 16alpha-羟基泼尼松龙
• 英文名: 16a-Hydroxyprednisolone
• 中文别名: 16A-羟基泼尼松龙; 布地奈德水解物; 16Α-羟基-泼尼松龙; 布地奈德杂质A; 11a和16b,17,21-四羟基孕甾-1,4-TIENE-3,20-二酮
• 英文别名: MFCD00872019; (11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione; 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-; EINECS 237-731-1; 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione; Budesonide Impurity 1

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 591.5±50.0 °C at 760 mmHg
• 熔点: 235-238ºC
• 分子式: C₂₁H₂₈O₆
• 分子量: 376.443
• 闪点: 325.6±26.6 °C
• 精确质量: 376.188599
• PSA: 115.06000
• LogP: 0.95
• 外观性状: 白色结晶固体
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.630
• 储存条件: -20°C Freezer

生物活性

• 描述: 16α-Hydroxyprednisolone 是糖皮质激素布地奈德的 22(R) epimer 构型经过 CYP3A 酶代谢生成的代谢物。
• 相关类别:
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Xavier Matabosch, et al. Identification of budesonide metabolites in human urine after oral administration. Anal Bioanal Chem. 2012 Aug;404(2):325-40.

  [2]. G Jönsson, et al. Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver. Drug Metab Dispos. 1995 Jan;23(1):137-42.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: 16Alpha-hydroxyprednisolone Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:16Alpha-hydroxyprednisolone CAS number:13951-70-7 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C21H28O6 Molecular weight:376.4 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2937210000

合成路线

1171-81-9 ~% 13951-70-7

文献：Journal of the American Chemical Society, , vol. 81, p. 1696,1699

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海关

海关编码	2914400090
中文概述	2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 丙酮报明包装
Summary	2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%