24939-03-5

• 常用中文名：聚胞苷酸
• 常用英文名：Polyinosinic-polycytidylic acid
• CAS号：24939-03-5
• 分子式：C₁₉H₂₇N₇O₁₆P₂
• 分子量：671.403
• 相关类别： 生物化工 生物反应调节剂
• 发布时间：2018-07-23 19:30:06
• 更新时间：2024-01-02 19:47:41
• 聚肌苷聚胞苷酸(Poly(I:C))是一种合成的双链RNA(dsRNA),是一种Toll样受体3(TLR3)激动剂。聚肌苷聚胞苷酸存在于一些病毒中,因此通常用于模拟细胞外dsRNA的作用。

名称

• 中文名: 聚胞苷酸
• 英文名: poly(I:C)
• 中文别名: 双链聚肌胞; 聚肌胞苷酸
• 英文别名: Polyinosinicacid-polycytidylicacid; Polyinosinic–polycytidylic acid; polyri:polyrc; polyi:c; Poly(I).Poly(C); polycpolyi; 5'-Inosinic acid homopolymer-5'-cytidylic acid homopolymer complex (1_1); 4-Amino-1-(5-O-phosphonopentofuranosyl)-2(1H)-pyrimidinone - 5'-inosinic acid (1:1); Polyinosinic; 2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphonopentofuranosyl)-, compd. with 5'-inosinic acid (1:1)

物化性质

• 沸点: 851.4ºC at 760 mmHg
• 分子式: C₁₉H₂₇N₇O₁₆P₂
• 分子量: 671.403
• 精确质量: 671.098938
• PSA: 377.00000
• 外观性状: 白色至米白色粉末或晶体
• 蒸汽压: 7.7E-31mmHg at 25°C
• 储存条件: −20°C
• 稳定性:

  本品为人工合成的干扰素诱导物，系由多聚肌苷酸和多聚胞苷酸组成的双股多聚核苷酸。由于干扰素有种属特异性，大量制备供临床应用有困难，故多应用干扰素诱导剂，诱导干扰素。此外聚肌胞尚有免疫佐剂的作用，能刺激网状内皮系统，增强吞噬细胞的吞噬功能，增强抗体的形成，刺激同种移植反应及迟发型过敏反应。有广谱抗病毒作用、抗肿瘤作用。

生物活性

• 描述: 聚肌苷聚胞苷酸(Poly(I:C))是一种合成的双链RNA(dsRNA),是一种Toll样受体3(TLR3)激动剂。聚肌苷聚胞苷酸存在于一些病毒中,因此通常用于模拟细胞外dsRNA的作用。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-738.

  [2]. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293(5):1364-1369.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TR0175000 CAS REGISTRY NUMBER : 24939-03-5 LAST UPDATED : 199106 DATA ITEMS CITED : 15 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 365 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 185 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9500 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Behavioral - excitement TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Blood - hemorrhage TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 220 ug/kg TOXIC EFFECTS : Vascular - other changes Blood - hemorrhage Nutritional and Gross Metabolic - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 28 mg/kg/28D-I TOXIC EFFECTS : Vascular - structural changes in vessels Blood - pigmented or nucleated red blood cells TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 mg/kg SEX/DURATION : female 8-9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 50 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility TYPE OF TEST : Cytogenetic analysis MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 250 ug/kg REFERENCE : VVIRAT Voprosy Virusologii. Problems of Virology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1956- Volume(issue)/page/year: (5),540,1982 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

安全

• 危害码 (欧洲): Xn
• WGK德国: 3
• RTECS号: TR0175000

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