5870-29-1

• 常用中文名：盐酸环喷托酯
• 常用英文名：Cyclopentolate Hydrochloride
• CAS号：5870-29-1
• 分子式：C₁₇H₂₆ClNO₃
• 分子量：327.84600
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-07-02 19:05:36
• 更新时间：2024-01-08 12:41:05
• Cyclopentolate (DL-Cyclopentolate) hydrochloride 是眼科常用的抗毒蕈碱药物。Cyclopentolate hydrochloride 是一种阿托品样毒蕈碱受体 (muscarinic receptor) 拮抗剂,对睫状肌毒蕈碱受体的 pKB 值为 7.8。

名称

• 中文名: 盐酸环喷托酯
• 英文名: Cyclopentolate Hydrochloride
• 中文别名: 环戊通
• 英文别名: 2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate,hydrochloride

物化性质

• 沸点: 409.7ºC at 760mmHg
• 熔点: 137-141°
• 分子式: C₁₇H₂₆ClNO₃
• 分子量: 327.84600
• 闪点: 201.5ºC
• 精确质量: 327.16000
• PSA: 49.77000
• LogP: 2.98210
• 储存条件: −20°C
• 水溶解性: Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9).

生物活性

• 描述: Cyclopentolate (DL-Cyclopentolate) hydrochloride 是眼科常用的抗毒蕈碱药物。Cyclopentolate hydrochloride 是一种阿托品样毒蕈碱受体 (muscarinic receptor) 拮抗剂,对睫状肌毒蕈碱受体的 pKB 值为 7.8。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 体内研究: 环戊酯(20 mg/kg)预处理大鼠的存活率为90%[3]。动物模型：80只Sprague-Dawley大鼠(急性、致死性有机磷农药(OP)中毒模型)[3]剂量：20 mg/kg(眼用环戊酸钠)给药：i.p.结果：经眼用环戊酸钠(20 mg/kg)预处理的大鼠存活率为90%。
• 参考文献:

  [1]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.

  [2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373.

  [3]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GY2450000 CHEMICAL NAME : Cyclopentaneacetic acid, 1-hydroxy-alpha-phenyl-, 2-(dimethylamino)ethyl ester, hydrochloride CAS REGISTRY NUMBER : 5870-29-1 LAST UPDATED : 199806 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C17-H25-N-O3.Cl-H MOLECULAR WEIGHT : 327.89 WISWESSER LINE NOTATION : L5TJ AYR&VO2N1&1 AQ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Human - child DOSE/DURATION : 40 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 87,634,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Ocular SPECIES OBSERVED : Human - child DOSE/DURATION : 50 ug/kg/I TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis REFERENCE : AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 105,91,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2235 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,444,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 960 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,314,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 314 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,141,1952 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 292 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,444,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,516,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2737 No. of Facilities: 112 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 3472 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2737 No. of Facilities: 131 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 2009 (estimated) No. of Female Employees: 1464 (estimated)

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: GY2450000
• 海关编码: 2922509090

海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%