77472-70-9

• 常用中文名：卡非多
• 常用英文名：Carphedon
• CAS号：77472-70-9
• 分子式：C₁₂H₁₄N₂O₂
• 分子量：218.252
• 相关类别： 有机原料 氨基化合物 含氧基氨基化合物
• 发布时间：2018-07-15 14:16:52
• 更新时间：2024-01-02 15:45:39
• Phenylpiracetam(Phenotropyl; Phenotropil)是piracetam的苯基衍生物,活性较piracetam高30到60倍。

名称

• 中文名: 4-苯基-2-吡咯烷酮-1-乙酰胺
• 英文名: 2-(2-Oxo-4-phenylpyrrolidin-1-yl)acetamide
• 中文别名: 苯基吡拉西坦; 芳妥西坦; 4-苯基吡拉西坦; 卡非多
• 英文别名: fonturacetam; UNII:99QW5JU66Y; Carphedon; Phenylpiracetam; 4-Phenyl-2-pyrrolidone-1-acetamide; 2-(2-Oxo-4-phenyl-1-pyrrolidinyl)acetamide; 1-Pyrrolidineacetamide, 2-oxo-4-phenyl-; 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide; 4-Phenylpiracetam; Phenotropil

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 486.4±45.0 °C at 760 mmHg
• 分子式: C₁₂H₁₄N₂O₂
• 分子量: 218.252
• 闪点: 247.9±28.7 °C
• 精确质量: 218.105530
• PSA: 64.39000
• LogP: 0.16
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.580

生物活性

• 描述: Phenylpiracetam(Phenotropyl; Phenotropil)是piracetam的苯基衍生物,活性较piracetam高30到60倍。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Zvejniece L, et al. Investigation into stereoselective pharmacological activity of phenotropil. Basic Clin Pharmacol Toxicol. 2011 Nov;109(5):407-12.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UX9663000 CHEMICAL NAME : 1-Pyrrolidineacetamide, 2-oxo-4-phenyl- CAS REGISTRY NUMBER : 77472-70-9 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H14-N2-O2 MOLECULAR WEIGHT : 218.28 WISWESSER LINE NOTATION : T5NVTJ A1VZ DR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,776,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Behavioral - analgesia REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 44,22,1981

安全

• 海关编码: 2933990090

合成路线

70291-40-6 ~99% 77472-70-9

文献：Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48

68497-63-2 ~81% 77472-70-9

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979

1198-97-6 ~% 77472-70-9

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979

106869-48-1 ~% 77472-70-9

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979

3060-41-1 ~% 77472-70-9

文献：J. Gen. Chem. USSR (Engl. Transl.), , vol. 58, # 5 p. 1093 - 1102,970 - 979

77519-55-2 ~% 77472-70-9

文献：Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48

55790-17-5 ~% 77472-70-9

文献：Pharmaceutical Chemistry Journal, , vol. 14, # 11 p. 776 - 780 Khimiko-Farmatsevticheskii Zhurnal, , vol. 14, # 11 p. 43 - 48

上下游产品

上游产品  6
70291-40-6 68497-63-2 1198-97-6 3060-41-1
77519-55-2 55790-17-5
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%