13133-07-8

• 常用中文名：耐斯糖
• 常用英文名：Nystose
• CAS号：13133-07-8
• 分子式：C₂₄H₄₂O₂₁
• 分子量：666.578
• 相关类别： 生物化工 糖类化合物 寡糖
• 发布时间：2018-07-30 17:59:18
• 更新时间：2024-01-04 17:09:28
• Nystose 是一个四糖,由两个果糖分子通过 β (1→2) 键与蔗糖的果糖基部分连接而成。

名称

• 中文名: 蔗果四糖
• 英文名: Nistose Trihydrate
• 中文别名: 耐斯糖
• 英文别名: α-D-Glucopyranoside, O-β-D-fructofuranosyl-(2->1)-O-β-D-fructofuranosyl-(2->1)-β-D-fructofuranosyl; β-D-Fructofuranosyl-(2->1)-β-D-fructofuranosyl-(2->1)-β-D-fructofuranosyl α-D-glucopyranoside; NISTOSE; Nystose Trihydrate; Fungitetraose; MFCD00191672; Fungitetraose Trihydrate; Nystose

物化性质

• 密度: 1.84±0.1 g/cm3
• 沸点: 1075.7±65.0 °C at 760 mmHg
• 熔点: 130-133 ºC
• 分子式: C₂₄H₄₂O₂₁
• 分子量: 666.578
• 闪点: 604.3±34.3 °C
• 精确质量: 666.221863
• PSA: 347.83000
• LogP: -1.76
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.694
• 储存条件: 2-8°C
• 水溶解性: Sparingly soluble (30 g/L) (25 ºC)
• 分子结构:

  1、 摩尔折射率：141.50

  2、 摩尔体积（m³/mol）：379.2

  3、 等张比容（90.2K）：1237.4

  4、 表面张力（dyne/cm）：113.4

  5、 极化率（10^-24cm³）：56.09

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:14

  3.氢键受体数量:21

  4.可旋转化学键数量:13

  5.互变异构体数量:无

  6.拓扑分子极性表面积348

  7.重原子数量:45

  8.表面电荷:0

  9.复杂度:964

  10.同位素原子数量:0

  11.确定原子立构中心数量:17

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：未确定

  2. 密度（g/mL, 25 ℃ ）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，5mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º，C=4，水）：10

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：未确定

生物活性

• 描述: Nystose 是一个四糖,由两个果糖分子通过 β (1→2) 键与蔗糖的果糖基部分连接而成。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
  天然产物 >> 糖和糖苷
• 参考文献:

  [1]. Ziesenitz SC, et al. In vitro assessment of nystose as a sugar substitute. J Nutr. 1987 May;117(5):846-51.

MSDS

Section I.Chemical Product and Company Identification Chemical Name Nistose Trihydrate Portland OR SynonymFungitetraose; Nystose Chemical FormulaC24H42O21 · 3H2O 13133-07-8 CAS Number Section II.Composition and Information on Ingredients Chemical NameCAS Number Percent (%)TLV/PELToxicology Data Nistose Trihydrate13133-07-8 Min. 98.0 (GC) Not available.Not available. Section III. Hazards Identification No specific information is available in our data base regarding the toxic effects of this material for humans. However, Acute Health Effects exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this compound. Chronic Health EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Section IV.First Aid Measures Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 Eye Contact minutes. Get medical attention. In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing Skin Contact before reuse. Thoroughly clean shoes before reuse. Get medical attention. If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or Inhalation waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not improve. IngestionINDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Section V.Fire and Explosion Data Not available. May be combustible at high temperature.Auto-Ignition Flammability Flash PointsFlammable LimitsNot available. Not available. Combustion ProductsThese products are toxic carbon oxides (CO, CO2). Fire Hazards Not available. Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards Risks of explosion of the product in presence of static discharge: Not available. Fire Fighting Media SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet. and Instructions Consult with local fire authorities before attempting large scale fire-fighting operations. Continued on Next Page Nistose Trihydrate Section VI.Accidental Release Measures Spill CleanupUse a shovel to put the material into a convenient waste disposal container. Finish cleaning the spill by rinsing any contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on Instructions disposal. Section VII. Handling and Storage Handling and StorageKeep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive heat and light. Do not breathe dust. Information Always store away from incompatible compounds such as oxidizing agents. Section VIII. Exposure Controls/Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended Engineering Controls exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a Personal Protection specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent. Exposure LimitsNot available. Section IX. Physical and Chemical Properties Solid. (White crystalline powder.)Solubility Physical state @ 20°CSoluble in water. Not available. Specific Gravity 666.58 (Anh.) Molecular WeightPartition CoefficientNot available. Boiling PointNot available.Vapor PressureNot applicable. Not available.Not available. Melting PointVapor Density Not available.VolatilityNot available. Refractive Index Not available. Critical TemperatureNot available.Odor ViscosityNot available.TasteNot available. Section X.Stability and Reactivity Data Stability This material is stable if stored under proper conditions. (See Section VII for instructions) Conditions of InstabilityAvoid excessive heat and light. Incompatibilities Reactive with oxidizing agents. Section XI. Toxicological Information Not available. RTECS Number Routes of ExposureEye Contact. Ingestion. Inhalation. Not available. Toxicity Data Chronic Toxic EffectsCARCINOGENIC EFFECTS : Not available. MUTAGENIC EFFECTS : Not available. TERATOGENIC EFFECTS : Not available. DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions. Acute Toxic EffectsNo specific information is available in our data base regarding the toxic effects of this material for humans. However, exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this compound. Section XII.Ecological Information Not available. Ecotoxicity Not available. Environmental Fate Continued on Next Page Nistose Trihydrate Section XIII. Disposal Considerations Waste DisposalRecycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Section XIV. Transport Information Not a DOT controlled material (United States). DOT Classification PIN NumberNot applicable. Proper Shipping NameNot applicable. Packing Group (PG)Not applicable. DOT Pictograms Section XV. Other Regulatory Information and Pictograms TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40 CFR 720.36 (C) for those products not on the inventory list: (EPA) (i) These products are supplied solely for use in research and development by or under the supervision of a technically qualified individual as defined in 40 CFR 720.0 et sec. (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be supplied on an MSDS sheet. WHMIS ClassificationNot controlled under WHMIS (Canada). (Canada) EINECS Number (EEC)Not available. EEC Risk StatementsNot available. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

合成路线

7512-17-6 57-50-1 ~0% 84039-32-7 470-69-9 详细

文献：Hirano, Takako; Wada, Toru; Iwai, Sumire; Sato, Hitoshi; Noda, Makoto; Juami, Mai; Nakamura, Masatoshi; Kumaki, Yasuko; Hakamata, Wataru; Nishio, Toshiyuki Carbohydrate Research, 2012 , vol. 353, p. 27 - 32

57-50-1 ~25% 57-48-7 59432-60-9 50-99-7 详细

文献：Journal of Molecular Catalysis B: Enzymatic, , vol. 97, p. 12 - 17

57-50-1 ~% 13133-07-8

文献：Journal of Biological Chemistry, , vol. 199, p. 217,219

57-50-1 ~% 2280-44-6 59432-60-9 470-69-9 详细

文献：Carbohydrate Research, , vol. 343, # 1 p. 56 - 66

57-50-1 ~% 57-48-7 50-99-7 56-81-5 详细

文献：Journal of Agricultural and Food Chemistry, , vol. 56, # 8 p. 2805 - 2809

57-50-1 ~% 492-62-6 470-23-5 470-69-9 详细

文献：Journal of Agricultural and Food Chemistry, , vol. 61, # 50 p. 12265 - 12273

59432-60-9 ~% 470-23-5 13133-07-8

文献：Journal of Agricultural and Food Chemistry, , vol. 51, # 1 p. 224 - 228

57-50-1 ~% 59432-60-9 50-99-7 470-69-9 详细

文献：Journal of Molecular Catalysis B: Enzymatic, , vol. 76, p. 44 - 51

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