97540-22-2

• 常用中文名：S-腺苷蛋氨酸对甲苯磺酸硫酸盐
• 常用英文名：S-Adenosyl-L-methionine disulfate tosylate
• CAS号：97540-22-2
• 分子式：C₂₂H₃₄N₆O₁₆S₄
• 分子量：766.796
• 相关类别： 生物化工 氨基酸及其衍生物 蛋氨酸类衍生物
• 发布时间：2018-03-10 08:00:00
• 更新时间：2024-01-02 11:32:35
• S-Adenosyl-L-methionine disulfate tosylate 是在所有哺乳动物细胞中合成的主要生物甲基供体,但在肝脏中含量最高。

名称

• 中文名: S-腺苷蛋氨酸对甲苯磺酸硫酸盐
• 英文名: S-Adenosyl-L-methionine disulfate tosylate
• 中文别名: S-腺苷-L-蛋氨酸对甲苯磺酸; 对甲苯磺酸二硫酸腺苷蛋氨酸; 腺苷蛋氨酸/SAM/S-腺苷-L-蛋氨酸对甲苯磺酸二硫酸盐
• 英文别名: S-Adenosyl-L-Methionine Disulfate p-toluenesulfonate; SAMe disulfate p-toluene-sulfonate; Ademetionine disulfate tosylate; MFCD01674068

物化性质

• 分子式: C₂₂H₃₄N₆O₁₆S₄
• 分子量: 766.796
• 精确质量: 766.091431
• PSA: 439.47000
• LogP: 1.20310
• 储存条件: -20℃

生物活性

• 描述: S-Adenosyl-L-methionine disulfate tosylate 是在所有哺乳动物细胞中合成的主要生物甲基供体,但在肝脏中含量最高。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Lu SC, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AU7334500 CAS REGISTRY NUMBER : 97540-22-2 LAST UPDATED : 199206 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C15-H23-N6-O5-S.H-O4-S.H2-O4-S.C7-H8-O3-S MOLECULAR WEIGHT : 766.86 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3320 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 15,4471,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2579 mg/kg TOXIC EFFECTS : Blood - normocytic anemia Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 15,4471,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 998 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 15,4471,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8100 mg/kg/90D-C TOXIC EFFECTS : Cardiac - changes in heart weight Liver - changes in liver weight Endocrine - changes in adrenal weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 15,4481,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10950 mg/kg/52W-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 15,4507,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 7 gm/kg/35D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume increased Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16,1927,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 73 gm/kg/52W-C TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in potassium REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16,1955,1988

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%