200393-05-1

• 常用中文名：腺苷蛋氨酸
• 常用英文名：Adenosylmethionine 1,4-butanedisulfonate
• CAS号：200393-05-1
• 分子式：C₁₉H₃₀N₆O₁₀S₃
• 分子量：598.67100
• 相关类别： 生物化工 氨基酸及其衍生物 蛋氨酸类衍生物
• 发布时间：2018-09-17 12:43:08
• 更新时间：2024-01-05 18:28:11
• S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine 1,4-butanedisulfonate 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine 1,4-butanedisulfonate 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine 1,4-butanedisulfonate 可用于肝病和骨关节炎的研究。

名称

• 中文名: S-腺苷蛋氨酸丁二磺酸盐
• 英文名: (2S)-2-({[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-{[( 4-sulfobutyl)sulfonyl]oxy}tetrahydro-2-furanyl]methyl}amino)-4-(m ethylsulfanyl)butanoic acid (non-preferred name)
• 中文别名: 腺苷蛋氨酸
• 英文别名: Adenosylmethionine 1,4-butanedisulfonate

物化性质

• 分子式: C₁₉H₃₀N₆O₁₀S₃
• 分子量: 598.67100
• 精确质量: 598.11900
• PSA: 288.21000
• LogP: 1.97940

生物活性

• 描述: S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 是一种具有口服活性的甲基供体。S-Adenosyl-L-methionine 1,4-butanedisulfonate 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂。S-Adenosyl-L-methionine 1,4-butanedisulfonate 在癌症中还具有抗增殖、促凋亡和抗转移作用。S-Adenosyl-L-methionine 1,4-butanedisulfonate 可用于肝病和骨关节炎的研究。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
• 参考文献:

  [1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

  [2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.

  [3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42.

  [4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224.

  [5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378.

  [6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74.

  [7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157.