70458-95-6

• 常用中文名：甲磺酸培氟沙星
• 常用英文名：Pefloxacin mesylate
• CAS号：70458-95-6
• 分子式：C₁₈H₂₄FN₃O₆S
• 分子量：429.463
• 相关类别： 原料药 人工合成抗感染类药 喹诺酮类药
• 发布时间：2018-02-08 08:00:00
• 更新时间：2024-01-02 19:26:25
• Pefloxacin是抗菌化合物,通过抑制DNA旋转酶来阻断DNA复制。

名称

• 中文名: 甲磺酸培氟沙星
• 英文名: pefloxacin mesylate
• 中文别名: 1-乙基-6-氟-7-(4-甲基哌嗪基)-4-氧代-1,4-二氢喹啉-3-羧酸甲磺酸盐
• 英文别名: EINECS 274-613-9; MFCD00865015; Pefloxacin mesylate; 1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,methanesulfonic acid

物化性质

• 密度: 1.32 g/cm3
• 沸点: 529.1ºC at 760 mmHg
• 分子式: C₁₈H₂₄FN₃O₆S
• 分子量: 429.463
• 闪点: 273.8ºC
• 精确质量: 429.136993
• PSA: 128.53000
• LogP: 2.19820
• 储存条件: -20°C

生物活性

• 描述: Pefloxacin是抗菌化合物,通过抑制DNA旋转酶来阻断DNA复制。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
  天然产物 >> 其他
• 参考文献:

  [1]. Drlica K, et al. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev. 1997 Sep;61(3):377-92.

  [2]. Hussy P, et al. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother. 1986 Jun;29(6):1073-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VB2002200 CHEMICAL NAME : 3-Quinolinecarboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperaziny l)-4-oxo-, monomethanesulfonate, dihydrate CAS REGISTRY NUMBER : 70458-95-6 LAST UPDATED : 199009 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H20-F-N3-O3.C-H4-O3-S.2H2-O MOLECULAR WEIGHT : 465.55 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 292,37,1981

安全

• 危害码 (欧洲): F,C
• 风险声明 (欧洲): R11
• 安全声明 (欧洲): 16-26-36/37/39-45
• 海关编码: 2933599090

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%