8047-67-4

• 常用中文名：蔗糖铁
• 常用英文名：Iron sucrose
• CAS号：8047-67-4
• 分子式：C₁₈H₂₄Fe₂O₂₄
• 分子量：736.059
• 相关类别： 生物化工 糖类化合物 双糖
• 发布时间：2018-09-30 18:21:25
• 更新时间：2024-01-02 18:54:45
• Iron sucrose (Iron saccharate) 是一种静脉注射铁制剂和一种促氧化剂。Iron sucrose 可用于缺铁性贫血的研究。

名称

• 中文名: 蔗糖铁
• 英文名: Iron saccharate
• 英文别名: Venofer; ferrivenin; Sucrofer; EINECS 232-464-7; MFCD00166305; Fesin; Hippiron; Iron(3+) D-glucarate (2:3); ironsugar; iviron; proferrin; feojectin

物化性质

• 沸点: 766.4ºC at 760 mmHg
• 熔点: MORE THAN 51ºC
• 分子式: C₁₈H₂₄Fe₂O₂₄
• 分子量: 736.059
• 闪点: 431.2ºC
• 精确质量: 735.935608
• PSA: 483.54000
• 储存条件: 室温，干燥

生物活性

• 描述: Iron sucrose (Iron saccharate) 是一种静脉注射铁制剂和一种促氧化剂。Iron sucrose 可用于缺铁性贫血的研究。
• 相关类别:
  研究领域 >> 代谢疾病
• 体外研究: 静脉注射蔗糖铁可使血红蛋白、平均红细胞体积、血清铁、铁蛋白和铁饱和度百分比显著增加,总铁结合能力相应降低[1]。体外生存分析表明,10毫米抗坏血酸暴露(2小时)克隆灭活40-80%的指数生长结肠癌细胞系(HCT116和HT29)。当结肠癌细胞在存在或不存在250μM铁蔗糖的情况下进行处理,然后冲洗,并使用10 mM抗坏血酸进行处理时,与单用药理学抗坏血酸相比,这些细胞显示出不稳定铁的水平增加,从而显著增加克隆细胞的杀伤作用[2]。细胞内粘附分子-1(ICAM-1)和血管细胞粘附分子-1(VCAM-1)在蔗糖铁处理的人主动脉内皮细胞中通过上调NADPH氧化酶(NOx)和NF-κB信号通路表达,增加U937细胞的粘附。在160μg/mL的浓度下,蔗糖铁显著地诱导细胞内ROS产生在1到3小时之间的时间依赖性增加,但在4小时时效果减弱[3]。
• 体内研究: 蔗糖铁能显著增加肾大部切除小鼠组织超氧化物的产生、组织细胞粘附分子的表达和内皮细胞的粘附性。蔗糖铁可加重去势ApoE-/-小鼠主动脉的动脉粥样硬化[3]。
• 参考文献:

  [1]. Kristiyana Kaneva, et al. Intravenous Iron Sucrose for Children With Iron Deficiency Anemia. J Pediatr Hematol Oncol. 2017 Jul;39(5):e259-e262.

  [2]. Kristin E Brandt, et al. Augmentation of Intracellular Iron Using Iron Sucrose Enhances the Toxicity of Pharmacological Ascorbate in Colon Cancer Cells. Redox Biol. 2018 Apr;14:82-87.

  [3]. Ko-Lin Kuo, et al. Iron Sucrose Accelerates Early Atherogenesis by Increasing Superoxide Production and Upregulating Adhesion Molecules in CKD. J Am Soc Nephrol. 2014 Nov;25(11):2596-606.

  [4]. Richard A Zager, et al. Combined Iron Sucrose and Protoporphyrin Treatment Protects Against Ischemic and Toxin-Mediated Acute Renal Failure. Kidney Int. 2016 Jul;90(1):67-76.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NO7700000 CHEMICAL NAME : Iron oxide, saccharated CAS REGISTRY NUMBER : 8047-67-4 LAST UPDATED : 199512 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,193,1982 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 150 mg(Fe)/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 10,375,1955 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1560 mg/kg/13W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 60,708,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 148 gm/kg/74W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,947,1959 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 104 gm/kg/13W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 24,109,1960 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 gm/kg/I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application REFERENCE : BECCAN Annual Report--Cancer Research Campaign. (Cancer Research Campaign, 2 Carlton House Terrace, London SW1Y 5AR, UK) V.1- 1924- Volume(issue)/page/year: 40,30,1962 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,161,1973 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,161,1973 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 12,102,1969

安全

• 海关编码: 3004909090

海关

海关编码	3004909090