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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：六甲蜜胺
纯度：98.0%
规格：
联系人：徐经理
联系电话：13311869306

上海吉至生化科技有限公司
上海市上海市奉贤区
产品名：2,4,6-三(二甲氨基)均三嗪
纯度：96.0%
规格：25g
联系人：刘佳
联系电话：18116092098

上海源溪生物科技有限公司
上海市上海市浦东新区
产品名：Altretamine (Hexalen)
纯度：98.9%
规格：1g
联系人：赖经理
联系电话：13564518121

上海脉铂医药科技有限公司
上海市上海市嘉定区
产品名：Altretamine
纯度：98.0%
规格：100mg/500mg/1g/1g
联系人：李先生
联系电话：18916172912

上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：2,4,6-三(二甲氨基)均三嗪
纯度：96.0%
规格：1ml/5g/25g/1g
联系人：阿拉丁
联系电话：400-620-6333

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]2，4，6-三(二甲氨基)均三嗪,99%
纯度：99.0%
规格：5mg/25mg/100mg/500mg
联系人：夏言
联系电话：18016376636

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645-05-6生产厂家

645-05-6

645-05-6结构式

常用中文名：2,4,6-三(二甲氨基)均三嗪
常用英文名：Altretamine
CAS号：645-05-6
分子式：C₉H₁₈N₆
分子量：210.279
相关类别：原料药抗肿瘤药烷化剂类抗肿瘤药
发布时间：2018-09-06 15:11:24
更新时间：2024-01-02 09:27:43
Altretamine 是一种烷化剂 (alkylator),具有抗肿瘤活性。

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中文名	六甲蜜胺
英文名	hexamethylmelamine
中文别名	六甲三聚氰胺 2,4,6-三(二甲氨基)均三嗪六甲聚腈胺
英文别名	HTM 1,3,5-Triazine-2,4,6-triamine, N,N,N,N,N,N-hexamethyl- Hexastat 2,4,6-tris<dimethylamino>-1,3,5-triazine HMM N2,N2,N4,N4,N6,N6-hexamethyl-1,3,5-triazine-2,4,6-triamine Hexalen EINECS 211-428-4 N,N,N’,N’,N″,N″-hexamethyl-1,3,5-triazine-2,4,6-triamine N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine hexamethylmelamine Altretamine Hexylen MFCD00549245 N,N,N,N,N,N-Hexamethyl-1,3,5-triazine-2,4,6-triamine NC 195 hemel

描述	Altretamine 是一种烷化剂 (alkylator),具有抗肿瘤活性。
相关类别	信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂研究领域 >> 癌症
体外研究	Altretamine是一种抗肿瘤药物[1]。
体内研究	Altretamine(100,133 mg/kg,ip。)与Irofulven联合使用可增加携带MV522细胞的小鼠的抗肿瘤作用[1]。
动物实验	小鼠[1] Balb / c nu / nu 4周龄雌性小鼠体重18-22g，接受sc注射8-10百万MV522细胞。在肿瘤植入后第10天开始，每周三次腹膜内施用阿尔特雷明，持续3周。以两个垂直直径测量肿瘤大小，并根据下式估计肿瘤重量（TW）：w = [（宽度）2×长度/ 2]。将阿尔特赖胺制备成在40％DMSO /生理盐水中的1-10mg / mL的储备溶液，并根据需要用10％DMSO /生理盐水稀释[1]。
参考文献	[1]. Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

密度	1.1±0.1 g/cm3
沸点	339.4±25.0 °C at 760 mmHg
熔点	171-175 °C(lit.)
分子式	C₉H₁₈N₆
分子量	210.279
闪点	159.1±23.2 °C
精确质量	210.159302
PSA	48.39000
LogP	2.42
外观性状	无色结晶固体
蒸汽压	0.0±0.7 mmHg at 25°C
折射率	1.610
储存条件	常温，2-8℃，避光，通风干燥处
稳定性	白色针状结晶。熔点170-173℃，易溶于氯仿，微溶于甲醇、乙醇，极微溶于水，对酸碱稳定。具升华性
水溶解性	Insoluble
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:6 4.可旋转化学键数量:3 5.互变异构体数量:无 6.拓扑分子极性表面积48.4 7.重原子数量:15 8.表面电荷:0 9.复杂度:148 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：白色针状结晶 2. 密度（g/mL,25/4℃）： 3. 相对蒸汽密度（g/mL,空气=1）： 4. 熔点（ºC）：171-175 5. 沸点（ºC,常压）：301 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率： 8. 闪点（ºC）： 9. 比旋光度（º）： 10. 自燃点或引燃温度（ºC）： 11. 蒸气压（kPa,25ºC）： 12. 饱和蒸气压（kPa,60ºC）： 13. 燃烧热（KJ/mol）： 14. 临界温度（ºC）： 15. 临界压力（KPa）： 16. 油水（辛醇/水）分配系数的对数值： 17. 爆炸上限（%,V/V）： 18. 爆炸下限（%,V/V）： 19. 溶解性：不溶于水

生态学数据:

通常对水是不危害的，若无政府许可，勿将材料排入周围环境

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS1050000

CHEMICAL NAME :: Melamine, hexamethyl-

CAS REGISTRY NUMBER :: 645-05-6

BEILSTEIN REFERENCE NO. :: 0195058

LAST UPDATED :: 199612

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C9-H18-N6

MOLECULAR WEIGHT :: 210.33

WISWESSER LINE NOTATION :: T6N CN ENJ BN1&1 DN1&1 FN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - leukopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Blood - hemorrhage

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - granulocytopenia Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 171 mg/kg

TOXIC EFFECTS :: Cardiac - cardiomyopathy including infarction Liver - hepatitis (hepatocellular necrosis), zonal

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 255 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 341 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3080 mg/kg/77D-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of endocrine pancreas Endocrine - hyperglycemia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 625 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 mg/kg/5D-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified) Blood - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 3108 mg/kg/3Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/46W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1240 mg/kg

SEX/DURATION :: male 62 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 320 mg/kg

SEX/DURATION :: female 6-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 320 mg/kg

SEX/DURATION :: female 9-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1160 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 80 mg/kg

SEX/DURATION :: female 15-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 780 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 250 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,500,1983

符号	GHS07
信号词	Warning
危害声明	H302-H315-H319-H335
警示性声明	P261-P305 + P351 + P338
个人防护装备	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	R22;R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	OS1050000
海关编码	2933699090

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海关编码	2933699090
中文概述	2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%