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56-94-0生产厂家

56-94-0价格

56-94-0

56-94-0结构式
56-94-0结构式
  • 常用中文名:地美溴铵
  • 常用英文名:Demecarium bromide
  • CAS号:56-94-0
  • 分子式:C32H52Br2N4O4
  • 分子量:716.588
  • 相关类别: 原料药 神经系统用药 拟胆碱药
  • 发布时间:2018-07-04 22:24:42
  • 更新时间:2024-01-05 10:02:46
  • Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。

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中文名 地美溴铵
英文名 demecarium bromide
中文别名 3,3'-(1,10-亚癸基双((甲基亚氨)甲酰氧基))双(N,N,N-三甲基苯铵))二溴化物
地美溴胺
待买卡农
英文别名 Tosmilen
3,3'-{1,10-Decanediylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide
Visumiotic
Demekastigmine bromide
3,3'-{Decane-1,10-diylbis[(methylcarbamoyl)oxy]}bis(N,N,N-trimethylanilinium) dibromide
Tonilen
trimethyl-[3-[methyl-[10-[methyl-[3-(trimethylazaniumyl)phenoxy]carbonylamino]decyl]carbamoyl]oxyphenyl]azanium,dibromide
3,3'-[1,10-Decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethylbenzenaminium]dibromide
Benzenaminium, 3,3'-[1,10-decanediylbis[(methylimino)carbonyloxy]]bis[N,N,N-trimethyl-, bromide (1:2)
Humorsol
Tosmicil
decamethylenebis[m-dimethylaminophenyl n-methylcarbamate] dimethobromide
Decamethylenebis[N-methylcarbamic Acid m-Dimethylaminophenyl Ester] Bromidethylate
Tosmilene
EINECS 200-301-9
Demecarium bromide
N,N'-Bis[3-trimethylammoniumphenoxycarbonyl]-N,N'-dimethyldecamethylenediamine Dibromide
Frumtosnil
Visumatic
描述 Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。
相关类别
靶点

Kiapp: 0.15 μM (Cholinesterase)[1]

体内研究 去甲肾上腺素(0.125和0.5%)引起长期瞳孔缩小,降低了正常血压眼和遗传性青光眼的小于眼内压(IOP)[1]。
参考文献

[1]. Brown JH, et al. Activation and blockade of cardiac muscarinic receptors by endogenous acetylcholine and cholinesterase inhibitors. J Pharmacol Exp Ther. 1982 Oct;223(1):20-4.

[2]. Gum GG, et al. Effect of topically applied demecarium bromide and echothiophate iodide on intraocular pressure and pupil size in beagles with normotensive eyes and beagles with inherited glaucoma. Am J Vet Res. 1993 Feb;54(2):287-93.

熔点 164 - 170ºC
分子式 C32H52Br2N4O4
分子量 716.588
精确质量 714.235535
PSA 59.08000
LogP 0.77020
储存条件 2-8℃
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:0

3.氢键受体数量:6

4.可旋转化学键数量:17

5.互变异构体数量:无

6.拓扑分子极性表面积59.1

7.重原子数量:42

8.表面电荷:0

9.复杂度:686

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BR3130000
CHEMICAL NAME :
Ammonium, (m-hydroxyphenyl)trimethyl-, bromide, decamethylenebis(methylcarbamate)
CAS REGISTRY NUMBER :
56-94-0
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C32-H52-N4-O4.2Br

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6490 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
29 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,307,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 1,168,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3186 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 9 No. of Employees: 3239 (estimated) No. of Female Employees: 1168 (estimated)

安全声明 (欧洲) S22-S26-S36/37-S36/37/39
危险品运输编码 3077
WGK德国 3
包装等级 III
危险类别 9