645-43-2

• 常用中文名：胍乙啶单硫酸盐
• 常用英文名：Guanethidine sulfate
• CAS号：645-43-2
• 分子式：C₁₀H₂₄N₄O₄S
• 分子量：296.387
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-07-07 19:29:29
• 更新时间：2024-01-01 18:33:45
• Guanethidine是一抗高血压药物，可降低儿茶酚胺的释放。

名称

• 中文名: 硫酸胍乙啶
• 英文名: guanethidine monosulfate
• 中文别名: 胍乙啶单硫酸盐; GUANETHI二NE 单磺酸盐
• 英文别名: 1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1); EINECS 211-442-0; Iporal; Guanethidine bisulfate; 1-[2-(1-Azocanyl)ethyl]guanidine sulfate; Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1); 2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid; Sanotensin; MFCD00035403; 1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1); 1-[2-(Azocan-1-yl)ethyl]guanidine sulfate; Guanethidine Sulfate; Ismelin sulfate; UNII-5UBY8Y002G; Guanetidin sulfate; Guanethidine monosulfate; 1-[2-(Azocan-1-yl)ethyl]guanidinsulfat; N-(2-Guanidino ethyl)heptamethylenimine sulfate; 1-(2-azocan-1-ylethyl)guanidine sulfate; Ismelin; guanethidine sulphate

物化性质

• 沸点: 345.6ºC at 760 mmHg
• 分子式: C₁₀H₂₄N₄O₄S
• 分子量: 296.387
• 闪点: 162.8ºC
• 精确质量: 296.151825
• PSA: 148.12000
• LogP: 2.29240
• 储存条件: -20°C

生物活性

• 描述: Guanethidine是一抗高血压药物,可降低儿茶酚胺的释放。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80.

  [2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MF3150000 CAS REGISTRY NUMBER : 645-43-2 LAST UPDATED : 198809 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C10-H22-N4.H2-O4-S MOLECULAR WEIGHT : 296.44 WISWESSER LINE NOTATION : T8NTJ A2MYZUM &S-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Human REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S25-S36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: MF3150000
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%