5633-20-5

• 常用中文名：奥昔布宁
• 常用英文名：oxybutynin
• CAS号：5633-20-5
• 分子式：C₂₂H₃₁NO₃
• 分子量：357.486
• 相关类别： 原料药 泌尿系统用药 尿崩症用药
• 发布时间：2018-04-21 08:00:00
• 更新时间：2024-01-02 13:21:38
• Oxybutynin是抗胆碱药,能缓解排尿困难等。

名称

• 中文名: 奥昔布宁
• 英文名: oxybutynin
• 中文别名: 尿多灵; 4-(二乙基氨基)丁-2-炔-1-基环己基(羟基)苯乙酸酯
• 英文别名: cyclohexyl(hydroxy)phénylacétate de 4-(diéthylamino)but-2-yn-1-yle; Cystrin; Oxybutyninum; EINECS 202-516-5; 4-(Diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate; Oxybutynine; benzeneacetic acid, a-cyclohexyl-a-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester; a-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester; a-Cyclohexyl-a-hydroxybenzene acetic acid 4-(diethylamino)-2-butynyl ester; Benzeneacetic acid, α-cyclohexyl-α-hydroxy-, 4-(diethylamino)-2-butyn-1-yl ester; Oxybutynin Base; 4-(Diethylamino)but-2-in-1-ylcyclohexyl(hydroxy)phenylacetat; 4-Diethylamino-2-butynyl phenyl cyclohexylglycolate; MFCD00865252; Oxybutinin; Lyrinel XL; 4-(Diethylamino)-2-butyn-1-yl cyclohexyl(hydroxy)phenylacetate; Pollakisu; 4-(diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; Oxytrol; Oxybutynin; Ditropan; Oxibutinina; Oxibutyninum

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 494.4±45.0 °C at 760 mmHg
• 熔点: 125 - 130ºC
• 分子式: C₂₂H₃₁NO₃
• 分子量: 357.486
• 闪点: 252.8±28.7 °C
• 精确质量: 357.230408
• PSA: 49.77000
• LogP: 5.19
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.546
• 储存条件: -20°C

生物活性

• 描述: Oxybutynin是抗胆碱药,能缓解排尿困难等。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tupker, R.A., A.M. Harmsze, and V.H. Deneer, Oxybutynin therapy for generalized hyperhidrosis. Archives of dermatology, 2006. 142(8): p. 1065-1086.

  [2]. Mijnhout, G., et al., Oxybutynin: dry days for patients with hyperhidrosis. Neth J Med, 2006. 64(9): p. 326-8.

  [3]. Schollhammer, M. and L. Misery, Treatment of hyperhidrosis with oxybutynin. Archives of dermatology, 2007. 143(4): p. 543-551.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Oxybutynin Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Oxybutynin CAS number:5633-20-5 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C22H31NO3 Molecular weight:357.5 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2922509090

合成路线

1508-65-2 ~% 5633-20-5

文献：WO2009/122429 A2, ; Page/Page column 7 ;

10575-25-4 4335-77-7 ~% 5633-20-5

文献：US2009/247628 A1, ; Page/Page column 53-54 ; US 20090247628 A1

22396-77-6 10399-13-0 ~% 5633-20-5

文献：WO2009/122429 A2, ; Page/Page column 6-7 ;

上下游产品

上游产品  5
1508-65-2 10575-25-4 4335-77-7 22396-77-6
10399-13-0
下游产品  2
10575-25-4 4335-77-7

海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%