3733-63-9

• 常用中文名：去氯羟嗪
• 常用英文名：Decloxizine
• CAS号：3733-63-9
• 分子式：C₂₁H₂₈N₂O₂
• 分子量：340.459
• 相关类别： 原料药 抗变态反应药 抗组胺药
• 发布时间：2018-06-24 19:35:08
• 更新时间：2024-01-05 14:49:26
• Decloxizine(UCB-1402; NSC289116)是组胺受体H1拮抗剂。

名称

• 中文名: 去氯羟嗪
• 英文名: 2-[2-(4-benzhydrylpiperazin-1-yl)ethoxy]ethanol
• 中文别名: 克喘羟嗪; 1-二苯甲基-4-(2-(2-羟基乙氧基)乙基)哌嗪
• 英文别名: Hydroxydiethylphenamine; Decloxizini hydrochloride; 1-(Diphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 1-Benzhydryl-4-[2-(2-hydroxyethoxy)ethyl]piperazine; 2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]ethanol; Decloxizini; Ethanol, 2-[2-[4- (diphenylmethyl)-1-piperazinyl]ethoxy]-; Decloxizine [INN]; 1-Benzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine; Decloxizina [INN-Spanish]; 2-{2-[4-(Diphenylmethyl)-1-piperazinyl]ethoxy}ethanol; 2-[2-(4-Benzhydryl-piperazino)-aethoxy]-aethanol; 2-[2-(4-benzhydryl-piperazino)-ethoxy]-ethanol; 2-(2-(4-Benzhydrylpiperazin-1-yl)ethoxy)ethanol; UCB 1402; 2-[2-(4-diphenylmethyl-piperazin-1-yl)-ethoxy]-ethanol; 4-(diphenylmethyl)-1-[2-(2-hydroxyethoxy)ethyl]piperazine; Decloxizine; 2-{2-[4-(Diphenylmethyl)piperazin-1-yl]ethoxy}ethanol; Decloxizinum [INN-Latin]; Ethanol, 2-[2-[4-(diphenylmethyl)-1-piperazinyl]ethoxy]-; DecloxizineHydrochloride

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 472.4±40.0 °C at 760 mmHg
• 分子式: C₂₁H₂₈N₂O₂
• 分子量: 340.459
• 闪点: 239.5±27.3 °C
• 精确质量: 340.215088
• PSA: 35.94000
• LogP: 1.43
• 外观性状: 白色或类似至白色粉末
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.576
• 储存条件: 通风低温干燥,与库房食品原料分开存放

生物活性

• 描述: Decloxizine(UCB-1402; NSC289116)是组胺受体H1拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KK7350000 CHEMICAL NAME : Ethanol, 2-(2-(4-(diphenylmethyl)-1-piperazinyl)ethoxy)- CAS REGISTRY NUMBER : 3733-63-9 BEILSTEIN REFERENCE NO. : 0306385 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C21-H28-N2-O2 MOLECULAR WEIGHT : 340.51 WISWESSER LINE NOTATION : T6N DNTJ AYR&R& D2O2Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 840 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 103 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 47 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 470 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 135 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,1002,1968 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 840 mg/kg SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1120 mg/kg SEX/DURATION : female 8-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5. Volume(issue)/page/year: 9,134,1968

安全

• 海关编码: 2933599090

合成路线

841-77-0 628-89-7 ~% 3733-63-9

文献：Takeda Chemical Industries, Ltd. Patent: US6248740 B1, 2001 ;

841-77-0 ~% 3733-63-9

文献：Takeda Chemical Industries, Ltd. Patent: EP1243271 A1, 2002 ;

上下游产品

上游产品  2
841-77-0 628-89-7
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海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%