224452-66-8

• 常用中文名：瑞他莫林
• 常用英文名：Retapamulin
• CAS号：224452-66-8
• 分子式：C₃₀H₄₇NO₄S
• 分子量：517.763
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-03-28 08:00:00
• 更新时间：2024-01-03 11:30:14
• Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。

名称

• 中文名: 瑞他莫林
• 英文名: Retapamulin
• 中文别名: 瑞他帕林
• 英文别名: Rebapamulin; Altabax; Altargo; (1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl {[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate; MFCD11045316; Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester; Retapamulin

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 594.9±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₇NO₄S
• 分子量: 517.763
• 闪点: 313.6±30.1 °C
• 精确质量: 517.322571
• PSA: 92.14000
• LogP: 5.45
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.571
• 储存条件: 2~8℃

生物活性

• 描述: Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 其他
• 参考文献:

  [1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60.

  [2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30.

  [3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8.

  [4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204.

  [5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517.

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

848130-83-6 60924-38-1 ~81% 224452-66-8

文献：Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; Shachan-Tov, Sharona Patent: US2009/149655 A1, 2009 ; Location in patent: Page/Page column 3; 5; 6 ;

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%