514-65-8

• 常用中文名：比哌立登
• 常用英文名：biperiden
• CAS号：514-65-8
• 分子式：C₂₁H₂₉NO
• 分子量：311.461
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-05-13 08:00:00
• 更新时间：2024-01-02 15:47:57
• Biperiden(KL 373)有抗帕金森症活性,是中枢M1胆碱受体阻断剂。

名称

• 中文名: 比哌立登
• 英文名: biperiden
• 中文别名: 3-哌啶基-1-苯基-双环庚烯基-1-丙醇; 碧卜利旦; 1-(5-双环[2.2.1]庚-2-烯基)-1-苯基-3-(1-哌啶基)丙-1-醇
• 英文别名: Biperidene [INN-French]; 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol; EINECS 208-184-6; 1-piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-; Biperideno; 1-norborn-5-en-2-yl-1-phenyl-3-piperidino-propan-1-ol; Biperidene; Biperidine; Beperiden; a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol; biperiden; UNII:0FRP6G56LD; 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol; 1-norborn-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol; 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol; Akineton; 1-Piperidinepropanol, α-[(1R,4R)-bicyclo[2.2.1]hept-5-en-2-yl]-α-phenyl-; 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol; 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol; 1-Piperidinepropanol, α-bicyclo(2.2.1)hept-5-en-2-yl-α-phenyl-; Biperidenum; a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol; Biperideno [INN-Spanish]; Biperidenum [INN-Latin]; 1-[(1R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol; 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(1-piperidinyl)-1-propanol

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 462.1±40.0 °C at 760 mmHg
• 熔点: 114ºC
• 分子式: C₂₁H₂₉NO
• 分子量: 311.461
• 闪点: 224.5±26.0 °C
• 精确质量: 311.224915
• PSA: 23.47000
• LogP: 4.01
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.583
• 储存条件: 通风低温干燥
• 水溶解性: 25.1 mg/L
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:2

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积:23.5

  7.重原子数量:23

  8.表面电荷:0

  9.复杂度:422

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:4

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Biperiden(KL 373)有抗帕金森症活性,是中枢M1胆碱受体阻断剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10)

  [2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8)

  [3]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TN3675000 CHEMICAL NAME : 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl- CAS REGISTRY NUMBER : 514-65-8 BEILSTEIN REFERENCE NO. : 0290038 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H29-N-O MOLECULAR WEIGHT : 311.51 WISWESSER LINE NOTATION : L55 A CUTJ FXQR&2- AT6NTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 161 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 195 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,204,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,204,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 340 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,636,1982

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%