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481-49-2生产厂家

481-49-2价格

481-49-2

481-49-2结构式
481-49-2结构式
  • 常用中文名:千金藤素
  • 常用英文名:Cepharanthine
  • CAS号:481-49-2
  • 分子式:C37H38N2O6
  • 分子量:606.707
  • 相关类别: 原料药 血液系统用药 促白细胞增生药
  • 发布时间:2018-09-17 13:03:13
  • 更新时间:2024-01-02 09:58:37
  • Cepharanthine 是从 Stephania cepharantha Hayata 中提取的生物碱,具有抗炎、抗氧化作用。Cepharanthine 能减轻肢体缺血再灌注 (I/R) 引起的肌肉和肾脏损伤。Cepharanthine 能诱导乳腺癌细胞发生自噬、凋亡和细胞周期阻滞。Cepharanthine 通过降低细胞膜的流动性来抑制 HIV-1 入侵。

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中文名 千金藤素
英文名 Cepharanthine
中文别名 金藤素
盐酸氯吉兰
千金藤碱
英文别名 O-Methylcepharanoline
(14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2.1.1.0.0.0]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dod ecaene
6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis-(oxy)]oxyacanthan
CEPHARANTHINE (RG)
(+)-cepharanthine
[methylenebis(oxy)]
Cepharanthine
sepharanthine
Cepharantin
CEPHARANTHINUM
(14S,27R)-22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2.1.1.0.0.0]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene
6',12'-Dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]oxyacanthan
6,7-methanediyldioxy-6',12'-dimethoxy-2,2'-dimethyl-oxyacanthane
Stephanotis
Cepharanthin
密度 1.2±0.1 g/cm3
熔点 140 - 145ºC
分子式 C37H38N2O6
分子量 606.707
精确质量 606.273010
PSA 61.86000
LogP 5.23
外观性状 黄色粉末
折射率 1.608
储存条件

棕色玻璃瓶密光密封包装。贮存于低温干燥处。

稳定性

按规格使用和贮存,不会发生分解,避免与氧化物接触

分子结构

1、 摩尔折射率:170.93

2、 摩尔体积(cm3/mol):494.2

3、 等张比容(90.2K):1280.8

4、 表面张力(dyne/cm):45.0

5、 极化率(10-24cm3):67.76

计算化学

1.疏水参数计算参考值(XlogP):6.5

2.氢键供体数量:0

3.氢键受体数量:8

4.可旋转化学键数量:2

5.互变异构体数量:无

6.拓扑分子极性表面积61.9

7.重原子数量:45

8.表面电荷:0

9.复杂度:994

10.同位素原子数量:0

11.确定原子立构中心数量:2

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

更多

1. 性状:淡黄色或黄色粉末

2. 密度(g/ m3,25/4℃):未确定

3. 相对蒸汽密度(g/cm3,空气=1):未确定

4. 熔点(ºC):148-150

5. 沸点(ºC,常压):未确定

6. 沸点(ºC,5.2kPa):未确定

7. 折射率:未确定

8. 闪点(ºC):未确定

9. 比旋光度(º):[α]20D为+277°(氯仿2%)。

10. 自燃点或引燃温度(ºC):未确定

11. 蒸气压(kPa,25ºC):未确定

12. 饱和蒸气压(kPa,60ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:易溶于酸性水溶液和乙醚、丙酮等有机溶剂,难溶于石油醚。

生态学数据:

该物质对环境可能有危害,对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FK0527000
CHEMICAL NAME :
Cepharanthine
CAS REGISTRY NUMBER :
481-49-2
BEILSTEIN REFERENCE NO. :
0075231
LAST UPDATED :
199807
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C37-H38-N2-O6
MOLECULAR WEIGHT :
606.77

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>155 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,648,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
57 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Skin and Appendages - hair
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,2413,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5400 mg/kg/30D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes Liver - other changes Blood - changes in spleen
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3640 mg/kg/26W-C
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg/30D-C
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - other changes Endocrine - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
182 mg/kg
SEX/DURATION :
male 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
182 mg/kg
SEX/DURATION :
female 26 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
1200 mg/kg
SEX/DURATION :
female 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 16,3855,1982

符号 GHS07
GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
危害码 (欧洲) T+
危险品运输编码 NONH for all modes of transport
RTECS号 FK0527000

1.取地不容根粉1kg,用0.6L 5% Na2CO3溶液润湿后放置2h,晾干,使植物组织充分吸收碱液。然后用苯1.5L浸泡3天后过滤,残渣用苯再泡2天,过滤后再用同量的苯浸泡一次,收集合并3次苯液,用10%盐酸萃取,在酸萃取过程中有大量白色粥样物析出,极易乳化。苯液用酸萃取至不含生物碱为止,萃取的酸液用饱和Na2CO3液碱化,碱化液再用氯仿萃取4次,合并氯仿萃取液,用无水硫酸钠干燥。蒸馏回收氯仿,得淡黄色泡沫状总生物碱,重17.5g左右。再将总碱溶于35ml丙酮中,放置2h,可析出白色针状结晶,过滤,用少量丙酮洗1次,干燥后得轮环藤碱1.8g。

取上述丙酮母液加苯2.5ml,放置过夜,析出柱状结晶,过滤,再用丙酮洗一次,干燥后得千金藤素苯加成物6.8g。再将其溶于氯仿,通过氧化铝层析柱(1g生物碱用3g氧化铝),浓缩,所得沉淀过滤和干燥后得淡黄色泡沫状无定形粉末,即为千金藤素。