1247-42-3

• 常用中文名：甲基泼尼松
• 常用英文名：meprednisone
• CAS号：1247-42-3
• 分子式：C₂₂H₂₈O₅
• 分子量：372.455
• 相关类别： 原料药 激素及调节内分泌功能类药 肾上腺皮质激素类药
• 发布时间：2018-09-15 08:18:27
• 更新时间：2024-01-02 15:46:24
• Meprednisone为糖皮质激素,可作用于糖皮质激素受体,强的松的甲基化衍生物。

名称

• 中文名: 甲基泼尼松
• 英文名: Meprednisone
• 中文别名: 甲泼尼松; 泼尼松; 甲基强的松
• 英文别名: (16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione; 16β-Methylprednisone; methylprednisone; deltisonab; (16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione; Deltisona B; 16b-Methylprednisone; Betapred; Betalone; Betapar; Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16β)-; 17,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione; meprednisone; 17,21-Dihydroxy-16b-methylpregna-1,4-diene-3,11,20-trione; Bitanisone; Betanisona

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 574.4±50.0 °C at 760 mmHg
• 熔点: 204-206ºC
• 分子式: C₂₂H₂₈O₅
• 分子量: 372.455
• 闪点: 315.2±26.6 °C
• 精确质量: 372.193665
• PSA: 91.67000
• LogP: 2.06
• 外观性状: 白色固体
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.595
• 储存条件: 2~8°C

生物活性

• 描述: Meprednisone为糖皮质激素,可作用于糖皮质激素受体,强的松的甲基化衍生物。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU4154090 CHEMICAL NAME : Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-beta-methyl- CAS REGISTRY NUMBER : 1247-42-3 LAST UPDATED : 198910 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C22-H28-O5 MOLECULAR WEIGHT : 372.50 WISWESSER LINE NOTATION : L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 14 mg/kg SEX/DURATION : female 16-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1098,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 6250 ug/kg SEX/DURATION : female 15-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,1042,1977

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2937210000

合成路线

1106-03-2 ~% 1247-42-3

文献：Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

1253-36-7 ~% 1247-42-3

文献：Journal of the American Chemical Society, , vol. 80, p. 4428 Journal of the American Chemical Society, , vol. 80, p. 4435 Journal of the American Chemical Society, , vol. 82, p. 4012,4025

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海关

海关编码	2937210000