190786-44-8

• 常用中文名：苯磺酸贝托司汀
• 常用英文名：Bepotastine Besilate
• CAS号：190786-44-8
• 分子式：C₂₇H₃₁ClN₂O₆S
• 分子量：547.063
• 相关类别： 原料药 抗肿瘤药 烷化剂类抗肿瘤药
• 发布时间：2018-06-12 16:35:15
• 更新时间：2024-01-05 10:46:53
• Bepotastine Beslilate (Bepreve)是组胺H1受体拮抗剂。

名称

• 中文名: 苯磺酸贝托司汀
• 英文名: bepotastine besylate
• 中文别名: 苯磺酸贝他斯汀; 苯磺酸贝托斯汀
• 英文别名: Bepotastine benzenesulfonate salt; UNII:6W18MO1QR3; Bepotastine Besilate; benzenesulfonic acid,4-[4-[(S)-(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid; 4-{4-[(S)-(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate; 4-{4-[(S)-(4-Chlorophenyl)(2-pyridinyl)methoxy]-1-piperidinyl}butanoic acid benzenesulfonate (1:1); Talion; Bepotastine besylate; UNII-6W18MO1QR3; TAU-284; Bepotastine benzenesulfonate; Betotastine besilate; 1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-, benzenesulfonate (1:1); Bepotastine (Beslilate); Bepreve; 4-{4-[(S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy]piperidin-1-yl}butanoic acid benzenesulfonate (1:1)

物化性质

• 沸点: 546.8ºC at 760 mmHg
• 熔点: 161-163°
• 分子式: C₂₇H₃₁ClN₂O₆S
• 分子量: 547.063
• 闪点: 284.5ºC
• 精确质量: 546.159119
• PSA: 125.41000
• LogP: 6.12220
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 8.63E-13mmHg at 25°C
• 储存条件: <0°C;存放于惰性气体之中;避免湿气 (吸湿),加热
• 水溶解性: 水溶性：微溶；可溶于：甲醇；微溶：乙醇；不溶：二乙醚

生物活性

• 描述: Bepotastine Beslilate (Bepreve)是组胺H1受体拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Cho KH, Choi HG.Development of novel bepotastine salicylate salt bioequivalent to the commercial bepotastine besilate in beagle dogs.Drug Dev Ind Pharm. 2012 Sep 10.

  [2]. Meier EJ, Torkildsen GL, Gow JA, McNamara TR, Gomes PJ, Williams JI; for the Bepotastine Besilate Ophthalmic Solutions Study Group.Integrated phase III trials of bepotastine besilate ophthalmic solution 1.5% for ocular itching associated with allergic con

  [3]. Kawakami T, Kimura S, Haga T, Doi R, Kyoya M, Nakagawa K, Soma Y.Health-related quality of life assessed by the effect of bepotastine besilate in patients with pruritus: importance of emotions score in atopic dermatitis.J Dermatol. 2012 Jun;39(6):527-30.

  [4]. Williams JI, Kennedy KS, Gow JA, Torkildsen GL, Abelson MB, Gomes PJ, McNamara TR; Bepotastine Besilate Ophthalmic Solutions Study Group.Prolonged effectiveness of bepotastine besilate ophthalmic solution for the treatment of ocular symptoms of allergic c

  [5]. Kida, Tetsuo; Fujii, Atsuko; Sakai, Osamu; Iemura, Masahito; Atsumi, Ikuyo; Wada, Tomoyuki; Sakaki, Hideyuki. Bepotastine besilate, a highly selective histamine H1 receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in i

安全

• 危害码 (欧洲): Xi