11041-94-4

• 常用中文名：盐酸去甲乌药碱
• 常用英文名：Higenamine HCl
• CAS号：11041-94-4
• 分子式：C₁₆H₁₈ClNO₃
• 分子量：307.772
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-02-22 08:00:00
• 更新时间：2024-01-02 14:42:25
• Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。

名称

• 中文名: 盐酸去甲乌头碱
• 英文名: 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1)
• 中文别名: 1-(4-羟基苄基)-6,7-二羟基-1,2,3,4-四氢异喹啉盐酸盐; 盐酸去甲乌药碱; 去甲乌药碱盐酸盐; 6,7-二羟基-1-(4-羟基苄基)-1,2,3,4-四氢异喹啉盐酸盐
• 英文别名: pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one; 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1); 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; Higenamine HCl; UNII:PQ432PID6E; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)

物化性质

• 沸点: 522.4ºC at 760 mmHg
• 分子式: C₁₆H₁₈ClNO₃
• 分子量: 307.772
• 闪点: 209.6ºC
• 精确质量: 307.097534
• PSA: 72.72000
• LogP: 3.36370
• 蒸汽压: 1.56E-11mmHg at 25°C
• 储存条件: 室温，干燥

生物活性

• 描述: Higenamine hydrochloride (Norcoclaurine hydrochloride) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine hydrochloride (Norcoclaurine hydrochloride) 具有抗凋亡作用。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 内分泌
• 靶点:

  β2-AR[1]

• 参考文献:

  [1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

  [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NX0484380 CHEMICAL NAME : 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)- CAS REGISTRY NUMBER : 11041-94-4 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H17-N-O3.Cl-H MOLECULAR WEIGHT : 307.80 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982

安全

• 海关编码: 2933499090

合成路线

117765-29-4 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

838-96-0 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

1699-54-3 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

39188-62-0 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

6547-53-1 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

1699-56-5 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

23428-48-0 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

23428-49-1 ~% 11041-94-4

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029

上下游产品

上游产品  7
838-96-0 1699-54-3 39188-62-0 6547-53-1
1699-56-5 23428-48-0 23428-49-1
下游产品  0

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%