236395-14-5

• 常用中文名：艾司利卡西平醋酸盐
• 常用英文名：Eslicarbazepine acetate
• CAS号：236395-14-5
• 分子式：C₁₇H₁₆N₂O₃
• 分子量：296.320
• 相关类别： 信号通路 跨膜转运 钠通道
• 发布时间：2018-09-16 18:54:26
• 更新时间：2024-01-02 14:54:39
• Eslicarbazepine acetate 是一种抗癫痫药物,也是 β-内分泌酶 (β-Secretase) 和电压门控钠离子通道 (sodium channel) 的双抑制剂。

名称

• 中文名: 醋酸艾司利卡西平
• 英文名: eslicarbazepine acetate
• 中文别名: 艾司利卡西平醋酸盐; 艾司利卡西平醋酸酯; (S)-(-)-10-乙酸基-10,11-二氢-5H-二苯[b,f]吖庚因-5-甲酰胺
• 英文别名: (10S)-5-Carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate; 5H-Dibenz[b,f]azepine-5-carboxamide, 10-(acetyloxy)-10,11-dihydro-, (10S)-; Exalief; EslicarbazepineAcetate; S-(−)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; [(5S)-11-carbamoyl-5,6-dihydrobenzo[b][1]benzazepin-5-yl] acetate; (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; Eslicarbazepine acetate; Aptiom; BIA 2-093; Zebinix; UNII-BEA68ZVB2K; Eslicarbazepine (acetate)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 427.4±55.0 °C at 760 mmHg
• 熔点: 183-185ºC
• 分子式: C₁₇H₁₆N₂O₃
• 分子量: 296.320
• 闪点: 212.3±31.5 °C
• 精确质量: 296.116089
• PSA: 72.63000
• LogP: 1.70
• 外观性状: 固体;White to Almost white powder to crystal
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.655
• 储存条件: 0-10°C;避免加热

生物活性

• 描述: Eslicarbazepine acetate 是一种抗癫痫药物,也是 β-内分泌酶 (β-Secretase) 和电压门控钠离子通道 (sodium channel) 的双抑制剂。
• 相关类别:
  信号通路 >> 神经信号通路 >> β-分泌
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 体内研究: Eslicarbazepine acetate是一种抗癫痫药物。它是一种前药,被激活为eslicarbazepine(S-licarbazepine),一种奥卡西平的活性代谢产物。 Eslicarbazepine acetate是(S)-(+)- licarbazepine的前药,是奥卡西平的主要活性代谢产物。因此,其作用机制与奥卡西平相同。 Eslicarbazepine acetate可能不会立即产生高剂量的(S)-(+)- licarbazepine,奥卡西平也是如此,理论上可以改善耐受性[1]。
• 参考文献:

  [1]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014.

MSDS

Eslicarbazepine Acetate SAFETY DATA SHEET Section1. IDENTIFICATION Product name:Eslicarbazepine Acetate 5.3 Section2. HAZARDS IDENTIFICATION GHS classification PHYSICAL HAZARDSNot classified HEALTH HAZARDS Specific target organ toxicityNarcotic effects - Single exposure [Category 3] ENVIRONMENTAL HAZARDSNot classified GHS label elements, including precautionary statements Pictograms or hazard symbols Signal wordWarning Hazard statements May cause drowsiness or dizziness Precautionary statements: Avoid breathing dust/fume/gas/mist/vapours/spray. [Prevention] Use only outdoors or in a well-ventilated area. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for [Response] breathing. Call a POISON CENTER or doctor/physician if you feel unwell. [Storage]Store in a well-ventilated place. Keep container tightly closed. Store locked up. [Disposal]Dispose of contents/container through a waste management company authorized by the local government. Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substance/mixture:Substance Components:Eslicarbazepine Acetate Percent:>98.0%(HPLC)(N) CAS Number:236395-14-5 BIA 2-093 , (S)-(-)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide Synonyms: Chemical Formula:C17H16N2O3 Eslicarbazepine Acetate Section4. FIRST AID MEASURES Inhalation:Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Skin contact:Remove/Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. If skin irritation or rash occurs: Get medical advice/attention. Eye contact:Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. Ingestion:Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. A rescuer should wear personal protective equipment, such as rubber gloves and air- Protection of first-aiders: tight goggles. Section5. FIRE-FIGHTING MEASURES Suitable extinguishingDry chemical, foam, water spray, carbon dioxide. media: Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to from the chemical:generate poisonous fume. Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing method according to the surrounding situation is used. Uninvolved persons should evacuate to a safe place. In case of fire in the surroundings: Remove movable containers if safe to do so. Special protectiveWhen extinguishing fire, be sure to wear personal protective equipment. equipment for firefighters: Section6. ACCIDENTAL RELEASE MEASURES Personal precautions,Use extra personal protective equipment (P3 filter respirator for toxic particles). Keep protective equipment and people away from and upwind of spill/leak. Entry to non-involved personnel should emergency procedures: be controlled around the leakage area by roping off, etc. Environmental precautions: Prevent product from entering drains. Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it. containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with up: appropriate laws and regulations. Section7. HANDLING AND STORAGE Precautions for safe handling Technical measures:Handling is performed in a well ventilated place. Wear suitable protective equipment. Prevent dispersion of dust. Wash hands and face thoroughly after handling. Use a closed system if possible. Use a local exhaust if dust or aerosol will be generated. Advice on safe handling: Avoid contact with skin, eyes and clothing. Conditions for safe storage, including any incompatibilities Storage conditions:Keep container tightly closed. Store in a refrigerator. Store locked up. Store away from incompatible materials such as oxidizing agents. Heat-sensitive Packaging material:Comply with laws. Section8. EXPOSURE CONTROLS / PERSONAL PROTECTION Engineering controls:Install a closed system or local exhaust. Also install safety shower and eye bath. Personal protective equipment Respiratory protection: Dust respirator, self-contained breathing apparatus(SCBA), supplied air respirator, etc. Use respirators approved under appropriate government standards and follow local and national regulations. Hand protection:Impervious gloves. Safety goggles. A face-shield, if the situation requires. Eye protection: Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires. Eslicarbazepine Acetate Section9. PHYSICAL AND CHEMICAL PROPERTIES Physical state (20°C):Solid Crystal- Powder Form: Colour:White - Almost white No data available Odour: pH: No data available Melting point/freezing point:187°C Boiling point/range:No data available No data available Flash point: Flammability or explosive limits: Lower:No data available No data available Upper: Relative density:No data available Solubility(ies): [Water]No data available [Other solvents] Soluble:Pyridine Section10. STABILITY AND REACTIVITY Chemical stability:Stable under proper conditions. Possibility of hazardous No special reactivity has been reported. reactions: Incompatible materials: Oxidizing agents Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx) products: Section11. TOXICOLOGICAL INFORMATION Acute Toxicity:No data available Skin corrosion/irritation: No data available Serious eyeNo data available damage/irritation: Germ cell mutagenicity: No data available Carcinogenicity: IARC =No data available No data available NTP = Reproductive toxicity:No data available Section12. ECOLOGICAL INFORMATION Ecotoxicity: Fish:No data available Crustacea:No data available Algae:No data available Persistence / degradability: No data available BioaccumulativeNo data available potential(BCF): Mobility in soil Log Pow:No data available Soil adsorption (Koc):No data available Henry's LawNo data available constant(PaM3/mol): Section13. DISPOSAL CONSIDERATIONS Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance. Eslicarbazepine Acetate Section14. TRANSPORT INFORMATION Hazards Class:Does not correspond to the classification standard of the United Nations UN-No:Not listed Section15. REGULATORY INFORMATION Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002 and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): 36/37/38
• 安全声明 (欧洲): 26-36
• 危险品运输编码: NONH for all modes of transport