6381-77-7

• 常用中文名：异抗坏血酸钠
• 常用英文名：Sodium erythorbate
• CAS号：6381-77-7
• 分子式：C₆H₈NaO₆
• 分子量：198.106
• 相关类别： 有机原料 有机金属盐
• 发布时间：2018-02-04 08:00:00
• 更新时间：2024-01-02 17:11:34
• Sodium erythorbate (D-Isoascorbic acid sodium) 是一种主要用于肉类、家禽和软饮料的食品添加剂,由不同来源的糖(如甜菜、甘蔗和玉米)制成。
• 1. 肉制品中：作为发色助剂，保持色泽，防止亚硝胺类（如亚硝酸盐）形成，改善风味，不易褪色。腌制咸菜：保持色泽，改善风味。
  2. 冷冻鱼虾：保持色泽，防止鱼表面氧化产生腐臭味。
  3. 啤酒及葡萄酒：在发酵后加入，防止异味和混浊，保持色香味，防止二次发酵
  4. 果汁及酱类：在装瓶时加入，保持天然VC，防止退色，保持原有风味。
  5. 水果储存：喷雾或配合柠檬酸使用，保持色泽风味，延长储存期。
  6. 罐头制品：在装罐前加入到汤汁，保持色香味。
  7. 用于面包中，可保持面包的色泽，自然风味和延长保质期。
  8. 中国<<食品添加剂使用卫生标准>规定用于面包.方便面.最大使用量为0.2g/kg,用于汤料，肉制品最大使用量1.0g/kg。

名称

• 中文名: 异抗坏血酸钠
• 英文名: Sodium erythorbate
• 中文别名: 异维生素 C 钠; D-2,3,5,6-四羟基-2-己烯酸-Y-内酯钠盐一水合物; D-异抗坏血酸钠盐一水合物; D-2,3,4,5,6-五羟基-2-己烯酸-4-内酯钠; D-异抗坏血酸钠
• 英文别名: EINECS 228-973-9; Sodium (2R)-2-[(1R)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate (non-preferred name); MFCD00067298; Penite; Prodalumnol; Rat Death Liquid; Prodalumnol double; sodium arsenylate; Sodium metaarsenite; Kill-All; SODIUM ARSENITE; Sodium isoascorbate monohydrate; L-ascorbic acid sodium salt; sodium L-ascorbate; Sodium (2R)-2-[(1R)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydro-3-furanolate; Arsenite,sodium; Sodium dioxoarsenate; Sodium (2R)-2-[(1R)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydro-3-furanolate (non-preferred name); Sodanit

物化性质

• 密度: 1.954g/cm3
• 沸点: 552.7ºC at 760mmHg
• 熔点: 168 - 170ºC
• 分子式: C₆H₈NaO₆
• 分子量: 198.106
• 闪点: 238.2ºC
• 精确质量: 198.014038
• PSA: 110.05000
• 外观性状: 白色结晶粉末
• 储存条件:

  1.避光，阴凉干燥处，密封保存

• 稳定性:

  1.干燥状态下在空气中稳定，遇光、热及铜、铁等金属离子时易氧化。

• 计算化学:

  1、 氢键供体数量：3

  2、 氢键受体数量：6

  3、 可旋转化学键数量：2

  4、 互变异构体数量：8

  5、 拓扑分子极性表面积（TPSA）：110

  6、 重原子数量：13

  7、 表面电荷：0

  8、 复杂度：237

  9、 同位素原子数量：0

  10、 确定原子立构中心数量： 2

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：2

• 更多:

  1. 性状：白色至黄白色结晶性粉末或颗粒，无臭，稍有咸味。

  2. 密度（g/mL,25℃）：1.77

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：218

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，12mmHg）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º，c=10, water)）：97

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：易溶于水(17g/100m1)，几不溶于乙醇。

生物活性

• 描述: Sodium erythorbate (D-Isoascorbic acid sodium) 是一种主要用于肉类、家禽和软饮料的食品添加剂,由不同来源的糖(如甜菜、甘蔗和玉米)制成。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他

MSDS

Name: d-(+)-Isoascorbic acid sodium salt 98% Material Safety Data Sheet Synonym: Sodium erythorbat CAS: 6381-77-7 Section 1 - Chemical Product MSDS Name:d-(+)-Isoascorbic acid sodium salt 98% Material Safety Data Sheet Synonym:Sodium erythorbat Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 6381-77-7 D-(+)-ISOASCORBIC ACID, SODIUM SALT 98 228-973-9 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid. Wash mouth out with water. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 6381-77-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: 5.5-8 @ 5% aq.sol. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 168 - 170 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: 15.3G/100ML WATER (25C) Specific Gravity/Density: Molecular Formula: C6H7O6Na Molecular Weight: 198.11 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents, strong bases, chemically active metals, aluminum, zinc, magnesium,copper. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 6381-77-7: MP8910000 LD50/LC50: CAS# 6381-77-7: Draize test, rabbit, eye: 100 mg Mild; Oral, rat: LD50 = >5 gm/kg. Carcinogenicity: D-(+)-ISOASCORBIC ACID, SODIUM SALT - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 6381-77-7: 0 Canada CAS# 6381-77-7 is listed on Canada's DSL List. CAS# 6381-77-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 6381-77-7 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、 急性毒性：LC50：15300mg/Kg（小白鼠经口） 生态学数据: 对水少是稍微危害的，不要让未稀释或大量的产品接触地下水、水道或污水系统 若无政府许可，勿将材料排入周围环境.

安全

• RTECS号: MP8910000

制备

1.以荧光假单胞菌Kl005或球状节杆菌K1022发酵D-葡萄糖产生2-酮基-D-葡萄糖酸(或钙盐)，再经酯化、转化和精制而成。发酵培养基组成(%)：葡萄糖18，酵母膏0.3，K2HPO4·3H2O 0.05，KH2PO40.05，MgSO4·7H2O0.025，CaC034.5；发酵温度控制在30～35℃，发酵周期30h，发酵转化率79.9%。发酵液加硫酸、活性炭以酸化和脱色，再用板框压滤得清液，收率96.6%；净化的发酵液经减压浓缩，加甲醇、硫酸回流酯化5h，冷冻结晶，离心甩滤得甲酯，酯化收率82.1%。甲酯用甲醇、碱性甲醇溶液在回流条件下进行转化，冷冻结晶，干燥得D-异抗坏血酸钠粗品，转化收率87．3%；将其溶解在热水中再加活性炭脱色，并保温压滤，清液经冷冻结晶、离心甩滤、洗涤、真空干燥得成品，母液回收，精制收率88.0%。

2.以葡萄糖为原料，发酵后再经酯化、转位精制制得。

3.由异抗坏血酸与氢氧化钠或碳酸钠反应制得。