145525-41-3

• 常用中文名：米格列奈钙
• 常用英文名：Mitiglinide (Calcium)
• CAS号：145525-41-3
• 分子式：C₁₉H₂₄NO₃Ca_0.5
• 分子量：334.44
• 相关类别： 原料药 激素及调节内分泌功能类药 胰腺激素及其它调节血糖药
• 发布时间：2018-02-18 08:00:00
• 更新时间：2024-01-03 21:05:33
• 【用途一】
  为全合成的抗Ⅱ型糖尿病新药

名称

• 中文名: 米格列奈钙
• 英文名: Calcium 2-benzyl-4-((3aR,7aS)-hexahydro-1H-isoindol-2(3H)-yl)-4-oxobutanoate
• 中文别名: 米格列奈; 双(2S)-2-苄基-3-(顺式全氢异吲哚-2-羰基)丙酸单钙盐
• 英文别名: Mitiglinide; Mitiglinide calcium; MFCD08458378; (aS,3aR,7aS)-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calcium salt; [2(S)-cis]-Octahydro-g-oxo-a-(phenylmethyl)-2H-isoindole-2-butanoic acid calclium salt; Mitiglinide hemicalcium salt; Mitiglinide (Calcium)

物化性质

• 密度: 1.175
• 沸点: 519.6ºC at 760 mmHg
• 熔点: 146-148ºC
• 分子式: C₁₉H₂₄NO₃Ca_0.5
• 分子量: 334.44
• 闪点: 268ºC
• PSA: 102.45000
• LogP: 5.59450
• 外观性状: 白色晶体粉末
• 蒸汽压: 1.27E-11mmHg at 25°C
• 储存条件: room temp

生物活性

• 描述: Mitiglinide(KAD-1229; S21403)是KATP通道拮抗剂,具有抗2型糖尿病活性。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Kiyoshi Ichikawa, Tokuhisa Yamato, Kazuma Ojima, et al. Effect Of Kad-1229, A Novel Hypoglycaemic Agent, On Plasma Glucose Levels After Meal Load In Type 2 Diabetic Rats. Clinical and Experimental Pharmacology and Physiology. 2002, 29 (5-6): 423-427

  [2]. Sunaga Y, Gonoi T, Shibasaki T, et al. The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.European Journal of Pharmacology.2001, 431(1):119

  [3]. Kiyoshi Ichikawa, Kazuyasu Maruyama, Makoto Murakami, et al. Absence of exacerbation of myocardial stunning in anesthetized dogs treated with KAD-1229, a novel hypoglycemic agent. European Journal of Pharmacology.2001, 3(23): 331-338

  [4]. Ohnota H, Kitamura T, Kinukawa M, et al. A rapid- and short-acting hypoglycemic agent KAD-1229 improves post-prandial hyperglycemia and diabetic complications in streptozotocin-induced non-insulin-dependent diabetes mellitus rats. Japanese Journal of Phar

  [5]. Hideo Mogamia, Hiroshi Shibataa, Romi Nobusawaa, et al. Inhibition of ATP-sensitive K+ channel by a non-sulfonylurea compound KAD-1229 in a pancreatic β-cell line, MIN 6 cell.. European Journal of Pharmacology: Molecular Pharmacology. 1994, 269(3): 293-29

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2942000000

海关

海关编码	2942000000