181183-52-8

• 常用中文名：依来曲普坦
• 常用英文名：Almotriptan
• CAS号：181183-52-8
• 分子式：C₂₁H₃₁N₃O₇S
• 分子量：469.552
• 相关类别： 生物化工 抑制剂 神经信号通路(Neuronal Signaling) 5-HT Receptor 激动剂
• 发布时间：2018-09-07 13:47:33
• 更新时间：2024-01-02 15:42:13
• Almotriptan苹果酸盐是5-HT1B/1D受体激动剂,可作用于偏头疼。

名称

• 中文名: 阿莫曲坦
• 英文名: almotriptan malate
• 中文别名: 依来曲普坦; 马来酸阿莫曲普坦; 苹果酸阿莫曲坦
• 英文别名: 2-Hydroxybutandisäure--N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamin(1:1); 2-Hydroxysuccinic acid - N,N-dimethyl-2-{5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1); N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine,2-hydroxybutanedioic acid; 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1); Almotriptan Malate; N,N-Dimethyl-N-(2-(5-((1-pyrrolidinylsulfonyl)methyl)-1H-indol-2-yl)ethyl)amine - 2-Hydroxysuccinic Acid (1:1); 2-Hydroxysuccinic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1); ALMOTRIPTAN MALEATE; Butanedioic acid, 2-hydroxy-, compd. with N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine (1:1); UNII:PJP312605E; LAS 31416 dl-malate acid; Axert; butanedioic acid, 2-hydroxy-, compd. with 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine (1:1); acide 2-hydroxybutanedioïque - N,N-diméthyl-2-{5-[(pyrrolidin-1-ylsulfonyl)méthyl]-1H-indol-3-yl}éthanamine (1:1); 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine Hydroxybutanedioate (1:1); Almotriptan (malate)

物化性质

• 密度: 1.27g/cm3
• 沸点: 538.7ºC at 760mmHg
• 熔点: 170-172ºC
• 分子式: C₂₁H₃₁N₃O₇S
• 分子量: 469.552
• 闪点: 279.6ºC
• 精确质量: 469.188263
• PSA: 159.62000
• LogP: 2.12290
• 外观性状: 淡黄色固体
• 蒸汽压: 1.13E-11mmHg at 25°C
• 储存条件: -20°C Freezer
• 水溶解性: 水溶性：可溶

生物活性

• 描述: Almotriptan苹果酸盐是5-HT1B/1D受体激动剂,可作用于偏头疼。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Bou J , et al. Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine. Eur J Pharmacol, 2000. 410(1): p. 33-41.

  [2]. Gras J, et al. Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics. Arzneimittelforschung, 2001. 51(9): p. 726-32.

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

617-48-1 154323-57-6 ~99% 181183-52-8

文献：MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SAHADEVA REDDY, Maramreddy; SATYANARAYANA, Komati Patent: WO2010/113183 A2, 2010 ; Location in patent: Page/Page column 26 ;

922735-96-4 617-48-1 ~% 181183-52-8

文献：US2008/234495 A1, ; Page/Page column 3 ;

922735-94-2 617-48-1 ~% 181183-52-8

文献：US2008/234495 A1, ; Page/Page column 3 ;

上下游产品

上游产品  2
617-48-1 154323-57-6
下游产品  0