544467-07-4

• 常用中文名：HIV-1整合酶抑制剂
• 常用英文名：HIV-1 integrase inhibitor
• CAS号：544467-07-4
• 分子式：C₁₁H₉N₃O₄
• 分子量：247.20700
• 相关类别： 生物化工 抑制剂 微生物学(Microbiology) Integrase 抑制剂
• 发布时间：2016-02-21 16:52:18
• 更新时间：2024-01-05 19:46:27
• HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。

名称

• 中文名: 4-[3-(叠氮基甲基)苯基]-2-羟基-4-氧代-2-丁烯酸
• 英文名: 2-Butenoic acid, 4-[3-(azidomethyl)phenyl]-2-hydroxy-4-oxo
• 英文别名: HIV-1 integrase inhibitor

物化性质

• 分子式: C₁₁H₉N₃O₄
• 分子量: 247.20700
• 精确质量: 247.05900
• PSA: 124.35000
• LogP: 1.65886
• 储存条件: 2-8℃

生物活性

• 描述: HIV-1 integrase inhibitor((Z)-4-(3-(azidomethyl)phenyl)-2-hydroxy-4-oxobut-2-enoic acid)可用于抗HIV。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Hobaika, Z.; Zargarian, L.; Maroun, R. G.; Mauffret, O.; Burke, T. R., Jr.; Fermandjian, S. HIV-1 Integrase and Virus and Cell DNAs: Complex Formation and Perturbation by Inhibitors of Integration. Neurochemical Research (2010), 35(6), 888-893.

  [2]. Loizidou, Eriketi Z.; Zeinalipour-Yazdi, Constantinos D.; Christofides, Tasos; Kostrikis, Leondios G. Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance. Bioorganic & Medicinal Chemistry (2009), 17(13), 4806-4818.

  [3]. Kawasuji T.Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore.J Med Chem. 2012 Sep 10.

  [4]. Yan A, Xuan S, Hu X.Classification of Active and Weakly Active ST Inhibitors of HIV-1 Integrase Using a Support Vector Machine.Comb Chem High Throughput Screen. 2012 Aug 28.

  [5]. Yu S, Zhao G.Development of Polyphenols as HIV-1 Integrase Inhibitors: A Summary and Perspective.Curr Med Chem. 2012 Aug 27.