卡替拉韦

• 常用名: 卡替拉韦
• 英文名: Cabotegravir
• CAS号: 1051375-10-0
• 分子量: 405.352
• 密度: 1.6±0.1 g/cm3
• 沸点: 664.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇F₂N₃O₅
• 熔点: N/A
• 闪点: 355.4±31.5 °C

卡替拉韦用途

Cabotegravir是一种有效的HIV整合酶抑制剂, 用于治疗和预防艾滋病毒感染, Cabotegravir抑制OAT1 (IC50为0.81 μM) 和OAT3 (IC50为0.41 μM)。

卡替拉韦名称

• 中文名: 卡替拉韦
• 英文名: SureCN82803

卡替拉韦生物活性

• 描述: Cabotegravir是一种有效的HIV整合酶抑制剂, 用于治疗和预防艾滋病毒感染, Cabotegravir抑制OAT1 (IC50为0.81 μM) 和OAT3 (IC50为0.41 μM)。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Reese MJ, Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2015 Sep 4:1-12.

  [2]. Reese MJ, et al. Drug interaction profile of the HIV integrase inhibitor cabotegravir: assessment from in vitro studies and a clinical investigation with midazolam. Xenobiotica. 2015 Sep 4:1-12.

  [3]. Bowers GD, Disposition and metabolism of cabotegravir: a comparison of biotransformation and excretion between different species and routes of administration in humans. Xenobiotica. 2015 Jul 1:1-16.

卡替拉韦物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 664.0±55.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇F₂N₃O₅
• 分子量: 405.352
• 闪点: 355.4±31.5 °C
• 精确质量: 405.113617
• PSA: 104.36000
• LogP: -1.70
• 外观性状: 粉末
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.661
• 储存条件: -20℃

卡替拉韦英文别名

• (3S,11aR)-N-(2,4-Difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide
• Cabotegravir
• Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-
• GSK1265744A
• unii-hmh0132z1q