Vortioxetine D8

• 常用名: Vortioxetine D8
• 英文名: Vortioxetine-d8
• CAS号: 2140316-62-5
• 分子量: 306.49
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₄D₈N₂S
• 熔点: N/A
• 闪点: N/A

Vortioxetine D8用途

Vortioxetine D8 是氘代标记的Vortioxetine。Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。

Vortioxetine D8名称

• 中文名: 沃替西汀 D8
• 英文名: Vortioxetine D8

Vortioxetine D8生物活性

• 描述: Vortioxetine D8 是氘代标记的Vortioxetine。Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 参考文献:

  [1]. Bang-Andersen B, Ruhland T, J rgensen M, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21.

  [2]. Guilloux JP, Mendez-David I, Pehrson A, Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013 May 28;73C:147-159.

  [3]. Theunissen EL, Street D, H?jer AM, A randomized trial on the acute and steady-state effects of a new antidepressant, vortioxetine (Lu AA21004), on actual driving and cognition. Clin Pharmacol Ther. 2013 Jun;93(6):493-501.

  [4]. Rothschild AJ, Mahableshwarkar AR, Jacobsen P, Vortioxetine (Lu AA21004) 5mg in generalized anxiety disorder: results of an 8-week randomized, double-blind, placebo-controlled clinical trial in the United States. Eur Neuropsychopharmacol. 2012 Dec;22(12):858-66.

  [5]. Mørk A, Pehrson A, Brennum LT, Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder. J Pharmacol Exp Ther. 2012 Mar;340(3):666-75.

Vortioxetine D8物理化学性质

• 分子式: C₁₈H₁₄D₈N₂S
• 分子量: 306.49
• 储存条件: -20°C，干燥，密封