苯并二氧六环-6-(1-哌啶基)甲酰胺

更新时间：2024-01-04 17:47:52

苯并二氧六环-6-(1-哌啶基)甲酰胺结构式	常用名	苯并二氧六环-6-(1-哌啶基)甲酰胺	英文名	CX546
	CAS号	215923-54-9	分子量	247.29000
	密度	1.215g/cm3	沸点	422.8ºC at 760 mmHg
	分子式	C₁₄H₁₇NO₃	熔点	N/A
	MSDS	美版	闪点	209.5ºC

苯并二氧六环-6-(1-哌啶基)甲酰胺用途

CX546是AMPAR受体选择性激动剂。

中文名	2-溴-1-(2,6-二氯苯基)乙酮
英文名	2,3-dihydro-1,4-benzodioxin-6-yl(piperidin-1-yl)methanone
中文别名	(2,3-二氢苯并[b][1,4]二噁英-6-基)(哌啶-1-基)甲酮 \| 苯并二氧六环-6-(1-哌啶基)甲酰胺 \| 1-(1,4-苯并二氧六环-6-基甲酰基)哌啶
英文别名	更多

描述	CX546是AMPAR受体选择性激动剂。
相关类别	信号通路 >> 自噬 >> 自噬信号通路 >> 跨膜转运 >> iGluR 信号通路 >> 神经信号通路 >> iGluR 研究领域 >> 神经疾病
参考文献	[1]. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21. [2]. Nagarajan N, et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63. [3]. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec;303(3):1075-85. [4]. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56.

描述

CX546是AMPAR受体选择性激动剂。

相关类别

信号通路 >> 自噬 >> 自噬

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

参考文献

[1]. Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21.

[2]. Nagarajan N, et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology. 2001 Nov;41(6):650-63.

[3]. Arai AC, et al. Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. J Pharmacol Exp Ther. 2002 Dec;303(3):1075-85.

[4]. Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56.

密度	1.215g/cm3
沸点	422.8ºC at 760 mmHg
分子式	C₁₄H₁₇NO₃
分子量	247.29000
闪点	209.5ºC
精确质量	247.12100
PSA	38.77000
LogP	2.02180
蒸汽压	2.34E-07mmHg at 25°C
折射率	1.573
储存条件	2-8℃

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
海关编码	2934999090

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.

Eur. Psychiatry 29(7) , 419-23, (2014)

Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that ...

Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

J. Pharmacol. Exp. Ther. 303 , 1075-1085, (2002)

CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured ...

Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.

Proc. Natl. Acad. Sci. U. S. A. 95 , 2597-2602, (1998)

To study regulation in vivo of the promoter for the neural cell adhesion molecule, N-CAM, we have used homologous recombination to insert the bacterial lacZ gene between the transcription and translat...

CX 546

Lopac-C-271

BDP 17

GR 87

CX546