托彻普

• 常用名: 托彻普
• 英文名: Torcetrapib
• CAS号: 262352-17-0
• 分子量: 600.47
• 密度: 1.4±0.1 g/cm3
• 沸点: 504.8±50.0 °C at 760 mmHg
• 分子式: C₂₆H₂₅F₉N₂O₄
• 熔点: 54-58ºC
• 闪点: 259.1±30.1 °C
• 符号: GHS07
• 信号词: Warning

托彻普用途

Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。

托彻普名称

• 中文名: 托彻普
• 英文名: torcetrapib
• 中文别名: (2R,4S)-4-[(3,5-双三氟甲基苄基)甲氧基甲酰氨基]-2-乙基-6-三氟甲基-3,4-二氢-2H-喹啉-1-羧酸乙酯

托彻普生物活性

• 描述: Torcetrapib(CP-529414)是CETP高效抑制剂,IC50值为37nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> CETP
  研究领域 >> 内分泌
• 参考文献:

  [1]. Clark RW, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7.

  [2]. Hu X, et al. Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9.

  [3]. Barter PJ, et al. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007 Nov 22;357(21):2109-22.

  [4]. Morehouse LA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits. J Lipid Res. 2007 Jun;48(6):1263-72.

托彻普物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 504.8±50.0 °C at 760 mmHg
• 熔点: 54-58ºC
• 分子式: C₂₆H₂₅F₉N₂O₄
• 分子量: 600.47
• 闪点: 259.1±30.1 °C
• PSA: 59.08000
• LogP: 7.76
• 外观性状: 液体
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.512
• 储存条件: Store at RT

托彻普安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport

托彻普英文别名

• 1(2H)-Quinolinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-3,4-dihydro-6-(trifluoromethyl)-, ethyl ester, (2R,4S)-
• Torcetrapib
• Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-1(2H)-quinolinecarboxylate
• MFCD08063631
• Ethyl (2R,4S)-4-{[3,5-bis(trifluoromethyl)benzyl](methoxycarbonyl)amino}-2-ethyl-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate
• ethyl (2R,4S)-4-[[3,5-bis(trifluoromethyl)phenyl]methyl-methoxycarbonylamino]-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinoline-1-carboxylate