2',5'-脱氧腺苷

更新时间：2024-01-03 17:12:36

2',5'-脱氧腺苷结构式	常用名	2',5'-脱氧腺苷	英文名	2',5'-Dideoxyadenosine
	CAS号	6698-26-6	分子量	235.24300
	密度	1.77 g/cm3	沸点	547ºC at 760 mmHg
	分子式	C₁₀H₁₃N₅O₂	熔点	N/A
	MSDS	美版	闪点	284.6ºC

2',5'-脱氧腺苷用途

2',5'-Dideoxyadenosine 是一种有效且非竞争性的腺苷酸环化酶 (adenylyl cyclase) 抑制剂,可以有效结合 P 位点,IC50 为 3 µM。2',5'-Dideoxyadenosine 是核苷类似物,在心脏中发挥强大的抗肾上腺素 (antiadrenergic) 作用。

中文名	2,5-二脱氧腺苷
英文名	2′,5′-Dideoxyadenosine
英文别名	更多

描述	2',5'-Dideoxyadenosine 是一种有效且非竞争性的腺苷酸环化酶 (adenylyl cyclase) 抑制剂,可以有效结合 P 位点,IC50 为 3 µM。2',5'-Dideoxyadenosine 是核苷类似物,在心脏中发挥强大的抗肾上腺素 (antiadrenergic) 作用。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷酸环化酶信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体研究领域 >> 代谢疾病
靶点	IC50: 3 µM (adenylyl cyclase)[1]
体外研究	2',5'-二脱氧腺苷(10μM,30 min)减少cAMP的产生并阻断卡巴胆碱(CCh)诱导的Ser845处GluA1的磷酸化[3]。2',5'-二脱氧腺苷(10μM,30min)阻断CCh诱导的Akt磷酸化增加,减弱CCh诱导的Ser2448磷酸化[3]。2',5'-二脱氧腺苷(20-150 mM)与腺苷一样,依赖性和可逆性地抑制异丙肾上腺素(8-54 pmol)刺激β肾上腺素能的正性肌力和变时效应,分别高达70%和50%[2]。Western Blot分析[3]细胞系：原代海马神经元浓度：10μM孵育时间：30min结果：卡巴胆碱(CCh)诱导的Ser845细胞cAMP生成减少,GluA1磷酸化受阻。
体内研究	2',5'-二脱氧腺苷(0.1 mg/kg；IP；预处理15分钟)完全抑制Fr•EtOAc对大鼠的利尿、利钠素和K+及Cl-保护作用[4]。动物模型：雄性Wistar大鼠(3-4月龄)[3]剂量：0.1 mg/kg给药：IP；预处理15min结果：完全抑制Fr•EtOAc对大鼠的利尿、利尿、保钾、保氯作用。
参考文献	[1]. Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53. [2]. Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8. [3]. Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631. [4]. Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.

密度	1.77 g/cm3
沸点	547ºC at 760 mmHg
分子式	C₁₀H₁₃N₅O₂
分子量	235.24300
闪点	284.6ºC
精确质量	235.10700
PSA	99.08000
LogP	0.65800
外观性状	白色固体
折射率	1.825
储存条件	-20°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport
海关编码	2934999090

(2S,3S,5R)-5-(6...

108906-82-7

~72%

2',5'-脱氧腺苷

6698-26-6

文献：Desaubry; Shoshani; Johnson Nucleosides and Nucleotides, 1995 , vol. 14, # 6 p. 1453 - 1460

2'-脱氧腺苷

958-09-8

2',5'-脱氧腺苷

6698-26-6

文献：Nucleosides and Nucleotides, , vol. 14, # 6 p. 1453 - 1460

2',5'-脱氧腺苷上游产品 2
CAS号108906-82-7 (2S,3S,5R)-5-(6... CAS号958-09-8 2'-脱氧腺苷
2',5'-脱氧腺苷下游产品 2
CAS号36792-88-8 2-Deoxy-β-D-rib... CAS号73-24-5 腺嘌呤

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2',5'-dideoxyadenosine