(D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN

更新时间：2024-01-01 18:48:00

(D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN结构式	常用名	(D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN	英文名	SKF 100398
	CAS号	77453-01-1	分子量	1136.39000
	密度	1.44g/cm3	沸点	N/A
	分子式	C₅₃H₇₇N₁₃O₁₁S₂	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

用途

SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物,能作为外源性和内源性 AVP 抗利尿作用的特异性拮抗剂。

中文名	(D(CH2)51,TYR(ET)2,VAL4,ARG8)-VASOPRESSIN
英文名	β-MERCAPTO-β,β-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ET)-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
英文别名	更多

描述	SKF 100398 (d(CH2)5Tyr(Et)VAVP) 是一种精氨酸加压素 (AVP) 类似物,能作为外源性和内源性 AVP 抗利尿作用的特异性拮抗剂。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体研究领域 >> 代谢疾病
体内研究	SKF 100398是外源性和内源性AVP通水作用的特异性拮抗剂[1]。SKF 100398(8个)μg/kg；i、消除AVP的抗利尿作用[1]。动物模型：雄性Sprague-Dawley大鼠(250-300g)[1]剂量：8μg/kg给药：静脉注射结果：完全阻断外源性AVP(4ng/kg体重)的抗利尿作用。
参考文献	[1]. S Ishikawa, et al. Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin. Am J Physiol. 1983 Nov;245(5 Pt 1):R713-9.

密度	1.44g/cm3
分子式	C₅₃H₇₇N₁₃O₁₁S₂
分子量	1136.39000
精确质量	1135.53000
PSA	431.92000
LogP	4.60970
折射率	1.676

符号	GHS07
信号词	Warning
危害声明	H332
个人防护装备	dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲)	Xn: Harmful;
风险声明 (欧洲)	20
安全声明 (欧洲)	36
危险品运输编码	NONH for all modes of transport

112453-06-2

(D(CH2)51,TYR(E...

77453-01-1

文献：Manning, Maurice; Lammek, Bernard; Kolodziejczyk, Alexander M. Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 701 - 706

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

Proc. Natl. Acad. Sci. U. S. A. 92(4) , 1013-7, (1995)

Water excretion by the kidney is regulated by the peptide hormone vasopressin. Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed fro...

Arginine vasopressin enhances pHi regulation in the presence of HCO3- by stimulating three acid-base transport systems.

Nature 337(6208) , 648-51, (1989)

Growth factors raise intracellular pH (pHi) by stimulating Na+/H+ exchange in the absence of HCO3-. In mutant cells that lack the Na+/H+ exchange activity, this alkalinization does not occur, and the ...

Pharmacological characterization of V1a vasopressin receptors in the rat cortical collecting duct.

Am. J. Physiol. 262 , F546-F553, (1992)

Vasopressin receptors in distal segments of the rat nephron were identified in isolated tubules using two labeled ligands: the [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid), 2-(O-meth...

M.W. 1136.41 C53H77N13O11S2

type 1 arginine vasopressin antagonist

(d(CH2)51,Tyr(Et)2,Val4,Arg8)-Vasopressin